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Many individual hosts are infected with multiple parasite species, and this may increase or decrease the pathogenicity of the infections. This phenomenon is termed heterologous reactivity and is potentially an important determinant of both patterns of morbidity and mortality and of the impact of ...


Woolhouse, Mark E.J.Thumbi, S.M.Jennings, A.Chase-Topping, M.Callaby, R.Kiara, Henry K.Oosthuizen, M.C.Mbole-Kariuki, Mary N.Conradie, I.Handel, I.G.Poole, Elizabeth J.Njiiri, E.Collins, N.E.Murray, G.Tapio, M.Auguet, O.T.Weir, W.Morrison, W. IvanKruuk, L.E.B.Bronsvoort, B.M. de C.Hanotte, Olivier H.Coetzer, K.Toye, Philip G.[Co-infections determine patterns of mortality in a population exposed to parasite infection]Co-infections determine patterns of mortality in a population exposed to parasite infection

Tick-borne diseases are a major impediment to improved productivity of livestock in sub-Saharan Africa. Improved control of these diseases would be assisted by detailed epidemiological data. Here we used longitudinal, serological data to determine the patterns of exposure to Theileria parva, Thei...


Kiara, Henry K.Jennings, A.Bronsvoort, B.M. de C.Hande, I.G.Mwangi, S.T.Mbole-Kariuki, Mary N.Wyk, I.C. vanPoole, Elizabeth J.Hanotte, Olivier H.Coetzer, J.A.W.Woolhouse, Mark E.J.Toye, Philip G.[A longitudinal assessment of the serological response to Theileria parva and other tick-borne parasites from birth to one year in a cohort of indigenous calves in western Kenya]A longitudinal assessment of the serological response to Theileria parva and other tick-borne parasites from birth to one year in a cohort of indigenous calves in western Kenya

Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a coho...


Callaby, R.Hanotte, Olivier H.Wyk, I.C. vanKiara, Henry K.Toye, Philip G.Mbole-Kariuki, Mary N.Jennings, A.Thumbi, S.M.Coetzer, J.A.W.Bronsvoort, B.M. de C.Knott, S.A.Woolhouse, Mark E.J.Kruuk, L.E.B.[Variation and covariation in strongyle infection in East African shorthorn zebu calves]Variation and covariation in strongyle infection in East African shorthorn zebu calves
Ayalew, Y.Gültas, M.Effa, K.Hanotte, Olivier H.Schmitt, A.O.[Identification of candidate signature genes and key regulators associated with Trypanotolerance in the Sheko Breed]Identification of candidate signature genes and key regulators associated with Trypanotolerance in the Sheko Breed

Most studies of infectious diseases in East African cattle have concentrated on gastro-intestinal parasites and vector-borne diseases. As a result, relatively little is known about viral diseases, except for those that are clinically symptomatic or which affect international trade such as foot an...


Callaby, R.Toye, Philip G.Jennings, A.Thumbi, S.M.Wyk, I.C. vanHanotte, Olivier H.Mbole-Kariuki, Mary N.Bronsvoort, B.M. de C.Kruuk, L.E.B.Woolhouse, Mark E.J.Kiara, Henry K.[Seroprevalence of respiratory viral pathogens of indigenous calves in western Kenya]Seroprevalence of respiratory viral pathogens of indigenous calves in western Kenya

To examine differences in cytokine profiles that may confer tolerance/susceptibility to bovine African trypanosomiasis, N'Dama (trypanotolerant, n = 8) and Boran (trypanosusceptible, n = 8) cattle were experimentally challenged with Trypanosoma congolense. Blood samples were collected over a 34-d...


O'Gorman, G.M.Park, S.D.E.Hill, E.W.Meade, K.G.Mitchell, L.C.Agaba, MorrisGibson, John P.Hanotte, Olivier H.Naessens, JanKemp, Stephen J.MacHugh, D.E.[Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense]Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense

An international multidisciplinary consortium is conducting a programme of research on the host response to trypanosome infection. This builds upon quantitative trait loci (QTL) mapping which identified genome regions influencing susceptibility to pathology following T. congolense infection in bo...


Kemp, Stephen J.Hanotte, Olivier H.Agaba, MorrisNoyes, H.A.Gibson, John P.Archibald, A.L.Rennie, C.Hulme, H.Brass, A.[Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons]Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons

Theileria parva schizont-infected lymphocyte culture isolates from western, central and coastal Kenya were analysed for size polymorphism at 30 T. parva-specific variable number tandem repeat (VNTR) loci using a panel of mini- and micro-satellite markers. The mean number of alleles ranged from 3 ...


Odongo, David O.Oura, C.A.Spooner, P.R.Kiara, Henry K.Mburu, D.Hanotte, Olivier H.Bishop, Richard P.[Linkage disequilibrium between alleles at highly polymorphic mini- and micro-satellite loci of Theileria parva isolated from cattle in three regions of Kenya]Linkage disequilibrium between alleles at highly polymorphic mini- and micro-satellite loci of Theileria parva isolated from cattle in three regions of Kenya

The comparative analysis of genome sequences emerging for several avian species with the fully sequenced chicken genome enables the genome-wide investigation of selective processes in functionally important chicken genes. In particular, because of pathogenic challenges it is expected that genes i...


Downing, T.Lynn, D.J.Connel, S.Lloyd, A.T.Bhuiyan, A.K.F.H.Silva, P.Naqvi, A.N.Sanfo, R.Sow, R.S.Overseas Development InstituteHanotte, Olivier H.O'Farrelly, C.O.Bradley, D.[Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus]Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus

Oocyan or blue/green eggshell colour is an autosomal dominant trait found in native chickens (Mapuche fowl) of Chile and in some of their descendants in European and North American modern breeds. We report here the identification of an endogenous avian retroviral (EAV-HP) insertion in oocyan Mapu...


Wragg, D.Mwacharo, Joram M.Alcalde, J.A.Wang, C.Han JianlinGongora, J.Gourichon, D.Tixier-Boichard, M.Hanotte, Olivier H.[Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl]Endogenous retrovirus EAV-HP linked to blue egg phenotype in Mapuche fowl

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