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Journal Article 2004

Autor: Hernández Valladares, M. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A.

A number of linkage studies in human populations have identified a locus ( pfbi) on Chromosome 5q31-q33 controlling Plasmodiun falciparum blood infection levels. This region contains numerous candidate genes encoding immunological molecules such as cytokines, growth factors and growth-factor rec...

Enlace original: https://cgspace.cgiar.org/handle/10568/32938

Investigación en Agricultura
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Hernández Valladares, M. ,  Rihet, P. ,  Ole-MoiYoi, O.K. ,  Iraqi, F.A. ,  [Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human chromosome 5q31-q33] ,  Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human chromosome 5q31-q33
Journal Article 2006-12-15

Autor: Hernández Valladares, M. Naessens, Jan Musoke, A.J. Sekikawa, K. Rihet, P. Ole-MoiYoi, O.K. Busher, P. Iraqi, F.A.

Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival...

Enlace original: https://cgspace.cgiar.org/handle/10568/1400

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Musoke, A.J. ,  Sekikawa, K. ,  Rihet, P. ,  Ole-MoiYoi, O.K. ,  Busher, P. ,  Iraqi, F.A. ,  [Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ] ,  Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ
Journal Article 2007

Autor: Hernández Valladares, M. Naessens, Jan Iraqi, F.A.

Gene-knockout mice have been extensively used in the study of several malaria-induced pathologies. Some investigators believe that the deficient, infected mice mimic disease aspects produced in the absence of the target gene, but others believe that the deficient mice models mainly explain the ef...

Enlace original: https://cgspace.cgiar.org/handle/10568/33188

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Iraqi, F.A. ,  [Gene-knockout mice in malaria research: Useful or misleading?] ,  Gene-knockout mice in malaria research: Useful or misleading?
Journal Article 2005

Autor: Hernández Valladares, M. Naessens, Jan Iraqi, F.A.

Murine models have proved to be excellent tools in the support of studies of the human genetic bases of malaria resistance and have enabled the mapping of 12 resistance loci, eight of them controlling parasitic levels and four controlling cerebral malaria. Further studies using this method have i...

Enlace original: https://cgspace.cgiar.org/handle/10568/33187

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Iraqi, F.A. ,  [Genetic resistance to malaria in mouse models] ,  Genetic resistance to malaria in mouse models
Journal Article 2005

Autor: Flori, L. Delahaye, N.F. Iraqi, F.A. Hernández Valladares, M. Fumoux, F. Rihet, P.

We have previously obtained strong evidence for linkage of mild malaria attack to the MHC region, with a peak close to the tumor necrosis factor (TNF) gene. We screened, for polymorphisms, the entire TNF gene in the same sample of 34 families comprising 197 individuals living in a Plasmodium falc...

Enlace original: https://cgspace.cgiar.org/handle/10568/28659

Investigación en Agricultura
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Flori, L. ,  Delahaye, N.F. ,  Iraqi, F.A. ,  Hernández Valladares, M. ,  Fumoux, F. ,  Rihet, P. ,  [TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso] ,  TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso
Journal Article 2004

Autor: Hernández Valladares, M. Naessens, Jan Gibson, John P. Musoke, A.J. Nagda, S.M. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A.

We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatel...

Enlace original: https://cgspace.cgiar.org/handle/10568/29204

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Gibson, John P. ,  Musoke, A.J. ,  Nagda, S.M. ,  Rihet, P. ,  Ole-MoiYoi, O.K. ,  Iraqi, F.A. ,  [Confirmation and dissection of QTL controlling resistance to malaria in mice] ,  Confirmation and dissection of QTL controlling resistance to malaria in mice
Journal Article 2004

Autor: Hernández Valladares, M. Naessens, Jan Nagda, S.M. Musoke, A.J. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A.

Susceptible A/J and more resistant C57BL/6J mice were infected with Plasmodium chabaudi chabaudi 54X, P.c. chabaudi AS and Plasmodium chabaudi adami 408XZ. As expected, most C57BL/6J mice survived the infections with the different isolates. But in contrast to previous observations, not all A/J ...

Enlace original: https://cgspace.cgiar.org/handle/10568/32918

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Nagda, S.M. ,  Musoke, A.J. ,  Rihet, P. ,  Ole-MoiYoi, O.K. ,  Iraqi, F.A. ,  [Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi] ,  Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi

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