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This review of the prospects for developing an immunization procedure against trypanosomiasis explores a number of promising avenues of research. Part I covers variable antigen types (VATs); metacyclic antigens; in vivo and in vitro attenuation; and molecular and genetic engineering. Part II, to ...


Murray, M.Barry, J.D.Morrison, W. IvanWilliams, R.O.Hirumi, H.Rovis, L.A.[A review of the prospects for vaccination in African trypanosomiasis. Part I]A review of the prospects for vaccination in African trypanosomiasis. Part I
Doyle, J.J.Hirumi, H.Hirumi, K.Lupton, E.N.Cross, G.A.M.[Antigenic variation in clones of animal-infective Trypanosoma brucei derived and maintained in vitro]Antigenic variation in clones of animal-infective Trypanosoma brucei derived and maintained in vitro

Transcripts which encode two metacyclic-form-specific variable surface glycoproteins (mVSGs) of Trypanosoma congolense IL3000 have been cloned into baculovirus expression vectors using a novel transfer vector, pAcL11. One of the recombinant baculoviruses (AcVSG1) expressed a mVSG as a glycoprotei...


Urakawa, T.Eshita, Y.Fukuma, T.Hirumi, H.Hirumi, K.Majiwa, P.A.O.[Expression of Trypanosoma congolense antigens in spodoptera frugiperdia insect cells]Expression of Trypanosoma congolense antigens in spodoptera frugiperdia insect cells

In part I of this review of the prospects of vaccination against African trypanosomiasis, contained in the previous issue of World Animal Review, the constraints in developing a vaccine were discussed and current knowledge on the molecular biology of the trypanosome and on antigenic variation wit...


Murray, M.Barry, J.D.Morrison, W. IvanWilliams, R.O.Hirumi, H.Rovis, L.A.[A review of the prospects for vaccination in African trypanosomiasis. Part II]A review of the prospects for vaccination in African trypanosomiasis. Part II

A monoclonal antibody (MAb)Tv27 employed in an antigen-detection enzyme immunosorbent assay (Ag-ELISA) for diagnosis of Trypanosoma vivax infection was shown to react with a T. vivax-specific protein of an approximate molecular weight of 10 kDa. This protein is diffusely distributed throughout th...


Masake, R.A.Ole-MoiYoi, O.K.Urakawa, T.Hirumi, H.Majiwa, P.A.O.Wells, C.W.Minja, S.H.Makau, J.M.Nantulya, V.M.[Immunological characterization and expression in Escherichia coli and Baculovirus systems of a Trypanosoma vivax antigen detected in the blood of infected animals]Immunological characterization and expression in Escherichia coli and Baculovirus systems of a Trypanosoma vivax antigen detected in the blood of infected animals
Doyle, J.J.Gee, A.L.W. deHirumi, H.[Variable antigen-associated difference in the growth characteristics of Trypanosoma brucei and Trypanosoma vivax]Variable antigen-associated difference in the growth characteristics of Trypanosoma brucei and Trypanosoma vivax

Presents results of trials conducted to detect antigenic variation in clones of variable antigen type 052 of Trypanosoma brucei, using immunofluorescent techniques.


Doyle, J.J.Hirumi, H.Gee, A.L.W. de[Mechanisms of antigenic variation in salivarian trypanosomes. The phenomenon]Mechanisms of antigenic variation in salivarian trypanosomes. The phenomenon
Barbet, K.L.McGuire, T.C.Musoke, A.J.Hirumi, H.[Cross-reacting determinants in trypanosome surface antigens]Cross-reacting determinants in trypanosome surface antigens

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