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This review of the prospects for developing an immunization procedure against trypanosomiasis explores a number of promising avenues of research. Part I covers variable antigen types (VATs); metacyclic antigens; in vivo and in vitro attenuation; and molecular and genetic engineering. Part II, to ...


Murray, M.Barry, J.D.Morrison, W. IvanWilliams, R.O.Hirumi, H.Rovis, L.A.[A review of the prospects for vaccination in African trypanosomiasis. Part I]A review of the prospects for vaccination in African trypanosomiasis. Part I
Doyle, J.J.Hirumi, H.Hirumi, K.Lupton, E.N.Cross, G.A.M.[Antigenic variation in clones of animal-infective Trypanosoma brucei derived and maintained in vitro]Antigenic variation in clones of animal-infective Trypanosoma brucei derived and maintained in vitro

Transcripts which encode two metacyclic-form-specific variable surface glycoproteins (mVSGs) of Trypanosoma congolense IL3000 have been cloned into baculovirus expression vectors using a novel transfer vector, pAcL11. One of the recombinant baculoviruses (AcVSG1) expressed a mVSG as a glycoprotei...


Urakawa, T.Eshita, Y.Fukuma, T.Hirumi, H.Hirumi, K.Majiwa, P.A.O.[Expression of Trypanosoma congolense antigens in spodoptera frugiperdia insect cells]Expression of Trypanosoma congolense antigens in spodoptera frugiperdia insect cells

In part I of this review of the prospects of vaccination against African trypanosomiasis, contained in the previous issue of World Animal Review, the constraints in developing a vaccine were discussed and current knowledge on the molecular biology of the trypanosome and on antigenic variation wit...


Murray, M.Barry, J.D.Morrison, W. IvanWilliams, R.O.Hirumi, H.Rovis, L.A.[A review of the prospects for vaccination in African trypanosomiasis. Part II]A review of the prospects for vaccination in African trypanosomiasis. Part II

A monoclonal antibody (MAb)Tv27 employed in an antigen-detection enzyme immunosorbent assay (Ag-ELISA) for diagnosis of Trypanosoma vivax infection was shown to react with a T. vivax-specific protein of an approximate molecular weight of 10 kDa. This protein is diffusely distributed throughout th...


Masake, R.A.Ole-MoiYoi, O.K.Urakawa, T.Hirumi, H.Majiwa, P.A.O.Wells, C.W.Minja, S.H.Makau, J.M.Nantulya, V.M.[Immunological characterization and expression in Escherichia coli and Baculovirus systems of a Trypanosoma vivax antigen detected in the blood of infected animals]Immunological characterization and expression in Escherichia coli and Baculovirus systems of a Trypanosoma vivax antigen detected in the blood of infected animals
Doyle, J.J.Gee, A.L.W. deHirumi, H.[Variable antigen-associated difference in the growth characteristics of Trypanosoma brucei and Trypanosoma vivax]Variable antigen-associated difference in the growth characteristics of Trypanosoma brucei and Trypanosoma vivax

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