This review of the prospects for developing an immunization procedure against trypanosomiasis explores a number of promising avenues of research. Part I covers variable antigen types (VATs); metacyclic antigens; in vivo and in vitro attenuation; and molecular and genetic engineering. Part II, to ...
Murray, M.
,
Barry, J.D.
,
Morrison, W. Ivan
,
Williams, R.O.
,
Hirumi, H.
,
Rovis, L.A.
,
[A review of the prospects for vaccination in African trypanosomiasis. Part I]
,
A review of the prospects for vaccination in African trypanosomiasis. Part I
Doyle, J.J.
,
Hirumi, H.
,
Hirumi, K.
,
Lupton, E.N.
,
Cross, G.A.M.
,
[Antigenic variation in clones of animal-infective Trypanosoma brucei derived and maintained in vitro]
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Antigenic variation in clones of animal-infective Trypanosoma brucei derived and maintained in vitro
Transcripts which encode two metacyclic-form-specific variable surface glycoproteins (mVSGs) of Trypanosoma congolense IL3000 have been cloned into baculovirus expression vectors using a novel transfer vector, pAcL11. One of the recombinant baculoviruses (AcVSG1) expressed a mVSG as a glycoprotei...
Urakawa, T.
,
Eshita, Y.
,
Fukuma, T.
,
Hirumi, H.
,
Hirumi, K.
,
Majiwa, P.A.O.
,
[Expression of Trypanosoma congolense antigens in spodoptera frugiperdia insect cells]
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Expression of Trypanosoma congolense antigens in spodoptera frugiperdia insect cells
In part I of this review of the prospects of vaccination against African trypanosomiasis, contained in the previous issue of World Animal Review, the constraints in developing a vaccine were discussed and current knowledge on the molecular biology of the trypanosome and on antigenic variation wit...
Murray, M.
,
Barry, J.D.
,
Morrison, W. Ivan
,
Williams, R.O.
,
Hirumi, H.
,
Rovis, L.A.
,
[A review of the prospects for vaccination in African trypanosomiasis. Part II]
,
A review of the prospects for vaccination in African trypanosomiasis. Part II
A monoclonal antibody (MAb)Tv27 employed in an antigen-detection enzyme immunosorbent assay (Ag-ELISA) for diagnosis of Trypanosoma vivax infection was shown to react with a T. vivax-specific protein of an approximate molecular weight of 10 kDa. This protein is diffusely distributed throughout th...
Masake, R.A.
,
Ole-MoiYoi, O.K.
,
Urakawa, T.
,
Hirumi, H.
,
Majiwa, P.A.O.
,
Wells, C.W.
,
Minja, S.H.
,
Makau, J.M.
,
Nantulya, V.M.
,
[Immunological characterization and expression in Escherichia coli and Baculovirus systems of a Trypanosoma vivax antigen detected in the blood of infected animals]
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Immunological characterization and expression in Escherichia coli and Baculovirus systems of a Trypanosoma vivax antigen detected in the blood of infected animals
Doyle, J.J.
,
Gee, A.L.W. de
,
Hirumi, H.
,
[Variable antigen-associated difference in the growth characteristics of Trypanosoma brucei and Trypanosoma vivax]
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Variable antigen-associated difference in the growth characteristics of Trypanosoma brucei and Trypanosoma vivax