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Holmes, P.H.Whitelaw, D.D.Bell, I.Moloo, S.K.Kirumi, H.Murray, M.Urquhart, G.M.[The association between samorin chemoprophylaxis and immune responses in cattle under experimental metacyclic Trypanosoma congolense challenge]The association between samorin chemoprophylaxis and immune responses in cattle under experimental metacyclic Trypanosoma congolense challenge

Isometamidium chloride is the most important chemoprophylactic agent used in the control of African bovine trypanosomiasis, although breakdowns in prophylaxis have been observed in the field. It is not usually apparent whether these breakdowns are due to inadequate drug dosage regimens, or to the...


Eisler, M.C.Maloo, S.H.Peregrine, A.S.Holmes, P.H.Thorpe, W.R.[Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya]Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya

The extent and significance of trypanocidal drug resistance was investigated in priority areas of three East and Southern African Countries under a project. The project was built on the results of two previous projects. Existing methods currently available for the demonstration of drug-resistance...


Eisler, M.C.Ndung'u, J.M.Murilla, G.Mdachi, R.M.Mbwambo, H.Sinyangwe, L.Machila, N.Delespaux, V.Geerts, S.Brandt, J.Peregrine, A.S.McDermott, John J.Holmes, P.H.[Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa]Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa

Besides the in vitro test, two tests are very commonly used for the detection of trypanocidal drug resistance: the tests in mice and in ruminants. Since it has been shown that several parameters such as the number of trypanosomes inoculated and the time of treatment might influence the outcome of...


Geerts, S.Ndung'u, J.M.Murilla, G.Mbwambo, H.Sirryangwe, L.Machila, N.Delespaux, V.Brandt, J.Peregrine, A.S.McDermott, John J.Holmes, P.H.Eisler, M.C.[In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants]In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants

This study has indicated that differences in susceptiblity to Trypanosoma congolense infection exist among the 3 main breeds of goats in Uganda namely, Kigezi, Mubende and small East African (SEA). The Kigezi goats appeared to be the most susceptibe suffering more severe anaemia, greater retardat...


Katunguka-Rwakishaya, E.Murray, M.Holmes, P.H.[Susceptibility of three breeds of Ugandan goats to experimental infection with Trypanosoma congolense]Susceptibility of three breeds of Ugandan goats to experimental infection with Trypanosoma congolense

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