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Eisler, M.C.Arowolo, R.O.A.Gault, E.A.Moloo, S.K.Holmes, P.H.Peregrine, A.S.[Isometamidium concentrations in the sera of Boran cattle. Correlation with prophylaxis against tsetse-transmitted Trypanosoma congolense]Isometamidium concentrations in the sera of Boran cattle. Correlation with prophylaxis against tsetse-transmitted Trypanosoma congolense
Sutherland, I.A.Moloo, S.K.Holmes, P.H.Peregrine, A.S.[Therapeutic and prophylactic activity of isometamidium chloride against a tsetse-transmitted drug-resistant clone of Trypanosoma congolense in Boran cattle]Therapeutic and prophylactic activity of isometamidium chloride against a tsetse-transmitted drug-resistant clone of Trypanosoma congolense in Boran cattle

The relationship between serum concentrations of the prophylactic trypanocidal drug isometamidium chloride and protection against tsetse challenge with two populations of Trypanosoma congolense was investigated in Boran (Bos indicus) cattle, using an isometamidium-ELISA. Isometamidium chloride (S...


Eisler, M.C.Gault, E.A.Moloo, S.K.Holmes, P.H.Peregrine, A.S.[Concentrations of isometamidium in the sera of cattle challenged with drug-resistant Trypanosoma congolense]Concentrations of isometamidium in the sera of cattle challenged with drug-resistant Trypanosoma congolense
Whitelaw, D.D.Bell, I.R.Holmes, P.H.Moloo, S.K.Hirumi, H.Urquhart, G.M.Murray, M.[Isometamidium chloride prophylaxis against Trypanosoma congolense challenge and the development of immune responses in Boran cattle]Isometamidium chloride prophylaxis against Trypanosoma congolense challenge and the development of immune responses in Boran cattle

Testing of trypanocidal drug sensitivity in stabilates of pathogenic trypanosomes derived from cattle continues to be problematic, in spite of Development of in vitro techniques, since these are generally complicated and costly for the resources available in developing country laboratories. Furth...


Geerts, S.Ndung'u, J.M.Murilla, G.Mbwambo, H.Sinyangwe, L.Machila, N.Delespaux, V.Brandt, J.Peregrine, A.S.McDermott, John J.Holmes, P.H.Eisler, M.C.[A simplified cost-effective method for area-wide testing of trypanocidal drug sensitivity of T. congolense in mice]A simplified cost-effective method for area-wide testing of trypanocidal drug sensitivity of T. congolense in mice

Control of trypanosomes in cattle, sheep and goats in endemic areas has depended largely on the use of chemotherapeutic or chemoprophylactic agents. One such agent is homidium. The normal use of homidium has been in the treatment of infections due to both Trypanosoma congolense and T.vivax in cat...


Murilla, G.A.Peregrine, A.S.Holmes, P.H.Eisler, M.C.Ndung'u, J.M.[Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle]Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle
Macaskill, J.A.Holmes, P.H.Whitelaw, D.D.Jennings, F.W.Urquhart, G.M.[Immune mechanisms in C57B1 mice genetically resistant to Trypanosoma congolense infection. 2. Aspects of the humoral response]Immune mechanisms in C57B1 mice genetically resistant to Trypanosoma congolense infection. 2. Aspects of the humoral response
Peregrine, A.S.Ogunyemi, O.Whitelaw, D.D.Holmes, P.H.Moloo, S.K.Hirumi, H.Urquhart, G.M.Murray, M.[Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense]Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense
Sutherland, I.A.Codjia, V.Moloo, S.K.Holmes, P.H.Peregrine, A.S.[Therapeutic activity of isometamidium chloride in Boran cattle against a clone of Trypanosoma congolense with a low level of drug resistance]Therapeutic activity of isometamidium chloride in Boran cattle against a clone of Trypanosoma congolense with a low level of drug resistance
Sutherland, I.A.Peregrine, A.S.Lonsdale-Eccles, J.D.Holmes, P.H.[Reduced accumulation of isometamidum by drug resistant Trypanosoma congolense]Reduced accumulation of isometamidum by drug resistant Trypanosoma congolense

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