Testing of trypanocidal drug sensitivity in stabilates of pathogenic trypanosomes derived from cattle continues to be problematic, in spite of Development of in vitro techniques, since these are generally complicated and costly for the resources available in developing country laboratories. Furth...
Geerts, S.
,
Ndung'u, J.M.
,
Murilla, G.
,
Mbwambo, H.
,
Sinyangwe, L.
,
Machila, N.
,
Delespaux, V.
,
Brandt, J.
,
Peregrine, A.S.
,
McDermott, John J.
,
Holmes, P.H.
,
Eisler, M.C.
,
[A simplified cost-effective method for area-wide testing of trypanocidal drug sensitivity of T. congolense in mice]
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A simplified cost-effective method for area-wide testing of trypanocidal drug sensitivity of T. congolense in mice
Control of trypanosomes in cattle, sheep and goats in endemic areas has depended largely on the use of chemotherapeutic or chemoprophylactic agents. One such agent is homidium. The normal use of homidium has been in the treatment of infections due to both Trypanosoma congolense and T.vivax in cat...
Murilla, G.A.
,
Peregrine, A.S.
,
Holmes, P.H.
,
Eisler, M.C.
,
Ndung'u, J.M.
,
[Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle]
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Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle
Control of trypanosomosis in cattle, sheep and goats in endemic areas has depended largely on the use of chemotherapeutic or chemoprophylactic agents. One such agent is homidium. The normal use of homidium has been in the treatment of infections due to both Trypanosoma congolense and T. vivax in ...
Murilla, G.
,
Peregrine, A.S.
,
Holmes, P.H.
,
Eisler, M.C.
,
Ndung'u, J.M.
,
[Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle]
,
Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle
Trypanocidal drugs are the most widely applied method of trypanosomosis control in Africa and the only control method in Latin America and Asia . Treatment recommendations and strategies for chemotherapeutic control of trypanosomosis depends on information of trypanosomosis risk and the prevalenc...
Eisler, M.C.
,
McDermott, John J.
,
Mdachi, R.
,
Murilla, G.
,
Sinyangwe, L.
,
Mubanga, J.
,
Machila, N.
,
Mbwambo, H.
,
Coleman, P.G.
,
Clausen, P.H.
,
Bauer, B.
,
Sidibe, I.
,
Geerts, S.
,
Holmes, P.H.
,
Peregrine, A.S.
,
[Rapid method for the assessment of trypanocidal drug resistance in the field]
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Rapid method for the assessment of trypanocidal drug resistance in the field
Holmes, P.H.
,
Whitelaw, D.D.
,
Bell, I.
,
Moloo, S.K.
,
Kirumi, H.
,
Murray, M.
,
Urquhart, G.M.
,
[The association between samorin chemoprophylaxis and immune responses in cattle under experimental metacyclic Trypanosoma congolense challenge]
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The association between samorin chemoprophylaxis and immune responses in cattle under experimental metacyclic Trypanosoma congolense challenge
Isometamidium chloride is the most important chemoprophylactic agent used in the control of African bovine trypanosomiasis, although breakdowns in prophylaxis have been observed in the field. It is not usually apparent whether these breakdowns are due to inadequate drug dosage regimens, or to the...
Eisler, M.C.
,
Maloo, S.H.
,
Peregrine, A.S.
,
Holmes, P.H.
,
Thorpe, W.R.
,
[Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya]
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Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya
The extent and significance of trypanocidal drug resistance was investigated in priority areas of three East and Southern African Countries under a project. The project was built on the results of two previous projects. Existing methods currently available for the demonstration of drug-resistance...
Eisler, M.C.
,
Ndung'u, J.M.
,
Murilla, G.
,
Mdachi, R.M.
,
Mbwambo, H.
,
Sinyangwe, L.
,
Machila, N.
,
Delespaux, V.
,
Geerts, S.
,
Brandt, J.
,
Peregrine, A.S.
,
McDermott, John J.
,
Holmes, P.H.
,
[Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa]
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Area-wide appraisal of drug resistance in trypanosomes infecting cattle in East and Southern Africa
Besides the in vitro test, two tests are very commonly used for the detection of trypanocidal drug resistance: the tests in mice and in ruminants. Since it has been shown that several parameters such as the number of trypanosomes inoculated and the time of treatment might influence the outcome of...
Geerts, S.
,
Ndung'u, J.M.
,
Murilla, G.
,
Mbwambo, H.
,
Sirryangwe, L.
,
Machila, N.
,
Delespaux, V.
,
Brandt, J.
,
Peregrine, A.S.
,
McDermott, John J.
,
Holmes, P.H.
,
Eisler, M.C.
,
[In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants]
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In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants