A survey to investigate resistance to drugs used in the treatment of bovine trypanosomosis was conducted in the eastern province of Zambia between 1996 and 1998. A cross-sectional study was conducted in three districts (Petauke, Katete, Lundazi) at 34 village sampling sites selected at random fr...
Sinyangwe, L.
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Delespaux, V.
,
Brandt, J.
,
Geerts, S.
,
Mubanga, J.
,
Machila, N.
,
Holmes, P.H.
,
Eisler, M.C.
,
[Trypanocidal drug resistance in eastern province of Zambia]
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Trypanocidal drug resistance in eastern province of Zambia
Resistance to the drugs used to control African animal trypanosomosis is increasingly recognised as a constraint to livestock production in sub-Saharan Africa. The most commonly used tests for detection of trypanocidal drug resistance are tests using mice or ruminants, but these suffer from lack ...
Eisler, M.C.
,
Brandt, J.
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Bauer, B.
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Clausen, P.H.
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Delespaux, V.
,
Holmes, P.H.
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Ilemobade, A.
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Machila, N.
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Mbwambo, H.
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McDermott, John J.
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Mehlitz, D.
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Murilla, G.
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Ndung'u, J.M.
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Peregrine, A.S.
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Sidibe, I.
,
Sinyangwe, L.
,
Geerts, S.
,
[Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle]
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Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle
Isometamidium chloride is the most important chemoprophylactic agent used in the control of African bovine trypanosomiasis, although breakdowns in prophylaxis have been observed in the field. It is not usually apparent whether these breakdowns are due to inadequate drug dosage regimens, or to the...
Eisler, M.C.
,
Maloo, S.H.
,
Peregrine, A.S.
,
Holmes, P.H.
,
Thorpe, W.R.
,
[Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya]
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Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya
Besides the in vitro test, two tests are very commonly used for the detection of trypanocidal drug resistance: the tests in mice and in ruminants. Since it has been shown that several parameters such as the number of trypanosomes inoculated and the time of treatment might influence the outcome of...
Geerts, S.
,
Ndung'u, J.M.
,
Murilla, G.
,
Mbwambo, H.
,
Sirryangwe, L.
,
Machila, N.
,
Delespaux, V.
,
Brandt, J.
,
Peregrine, A.S.
,
McDermott, John J.
,
Holmes, P.H.
,
Eisler, M.C.
,
[In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants]
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In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants