The relationship between serum concentrations of the prophylactic trypanocidal drug isometamidium chloride and protection against tsetse challenge with two populations of Trypanosoma congolense was investigated in Boran (Bos indicus) cattle, using an isometamidium-ELISA. Isometamidium chloride (S...
Eisler, M.C.
,
Gault, E.A.
,
Moloo, S.K.
,
Holmes, P.H.
,
Peregrine, A.S.
,
[Concentrations of isometamidium in the sera of cattle challenged with drug-resistant Trypanosoma congolense]
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Concentrations of isometamidium in the sera of cattle challenged with drug-resistant Trypanosoma congolense
Two groups of five Boran (Bos indicus) cattle were infected with one of two populations of Trypanosoma congolense; one drug-sensitive (IL1180), and one drug-resistant (IL3330). The animals were then treated intramuscularly with homidium bromide at a dose rate of 1.0 mg kg - bodyweight 7 days afte...
Murilla, G.A.
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Peregrine, A.S.
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Ndung'u, J.M.
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Holmes, P.H.
,
Eisler, M.C.
,
[The effects of drug-sensitive and drug-resistant Trypanosoma congolense infections on the pharmacokinetics of homidium in Boran cattle]
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The effects of drug-sensitive and drug-resistant Trypanosoma congolense infections on the pharmacokinetics of homidium in Boran cattle
Isometamidium chloride is the most important chemoprophylactic agent used in the control of African bovine trypanosomiasis, although breakdowns in prophylaxis have been observed in the field. It is not usually apparent whether these breakdowns are due to inadequate drug dosage regimens, or to the...
Eisler, M.C.
,
Maloo, S.H.
,
Peregrine, A.S.
,
Holmes, P.H.
,
Thorpe, W.R.
,
[Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya]
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Use of the isometamidium Elisa to measure serum concentrations of the drug in Jersey dairy cattle in Kenya