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Two groups of five Boran (Bos indicus) cattle were infected with one of two populations of Trypanosoma congolense; one drug-sensitive (IL1180), and one drug-resistant (IL3330). The animals were then treated intramuscularly with homidium bromide at a dose rate of 1.0 mg kg - bodyweight 7 days afte...


Murilla, G.A.Peregrine, A.S.Ndung'u, J.M.Holmes, P.H.Eisler, M.C.[The effects of drug-sensitive and drug-resistant Trypanosoma congolense infections on the pharmacokinetics of homidium in Boran cattle]The effects of drug-sensitive and drug-resistant Trypanosoma congolense infections on the pharmacokinetics of homidium in Boran cattle

Control of trypanosomosis in cattle, sheep and goats in endemic areas has depended largely on the use of chemotherapeutic or chemoprophylactic agents. One such agent is homidium. The normal use of homidium has been in the treatment of infections due to both Trypanosoma congolense and T. vivax in ...


Murilla, G.Peregrine, A.S.Holmes, P.H.Eisler, M.C.Ndung'u, J.M.[Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle]Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle
Holmes, P.H.Whitelaw, D.D.Bell, I.Moloo, S.K.Kirumi, H.Murray, M.Urquhart, G.M.[The association between samorin chemoprophylaxis and immune responses in cattle under experimental metacyclic Trypanosoma congolense challenge]The association between samorin chemoprophylaxis and immune responses in cattle under experimental metacyclic Trypanosoma congolense challenge

This study has indicated that differences in susceptiblity to Trypanosoma congolense infection exist among the 3 main breeds of goats in Uganda namely, Kigezi, Mubende and small East African (SEA). The Kigezi goats appeared to be the most susceptibe suffering more severe anaemia, greater retardat...


Katunguka-Rwakishaya, E.Murray, M.Holmes, P.H.[Susceptibility of three breeds of Ugandan goats to experimental infection with Trypanosoma congolense]Susceptibility of three breeds of Ugandan goats to experimental infection with Trypanosoma congolense

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