Mice were immunized with either an isometamidium-human serum albumin (HSA) conjugate or an isometamidium-porcine thyroglobulin conjugate (PTG). Thereafter, monoclonal antibodies (MAbs) IL-A 1001, IL-A 1002, IL-A 1003, 5F7.B7, and 5F7.C9 were generated and selected on the basis that they recognize...
Peregrine, A.S.
,
Eisler, M.C.
,
Katende, J.
,
Flynn, J.N.
,
Gault, E.A.
,
Kinabo, L.D.B.
,
Holmes, P.H.
,
[Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium]
,
Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium
Control of trypanosomes in cattle, sheep and goats in endemic areas has depended largely on the use of chemotherapeutic or chemoprophylactic agents. One such agent is homidium. The normal use of homidium has been in the treatment of infections due to both Trypanosoma congolense and T.vivax in cat...
Murilla, G.A.
,
Peregrine, A.S.
,
Holmes, P.H.
,
Eisler, M.C.
,
Ndung'u, J.M.
,
[Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle]
,
Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle
Peregrine, A.S.
,
Ogunyemi, O.
,
Whitelaw, D.D.
,
Holmes, P.H.
,
Moloo, S.K.
,
Hirumi, H.
,
Urquhart, G.M.
,
Murray, M.
,
[Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense]
,
Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense
Control of trypanosomosis in cattle, sheep and goats in endemic areas has depended largely on the use of chemotherapeutic or chemoprophylactic agents. One such agent is homidium. The normal use of homidium has been in the treatment of infections due to both Trypanosoma congolense and T. vivax in ...
Murilla, G.
,
Peregrine, A.S.
,
Holmes, P.H.
,
Eisler, M.C.
,
Ndung'u, J.M.
,
[Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle]
,
Investigation into the effects of Trypanosoma congolense infections on the pharmacokinetics of Homidium in Boran cattle
Holmes, P.H.
,
Whitelaw, D.D.
,
Bell, I.
,
Moloo, S.K.
,
Kirumi, H.
,
Murray, M.
,
Urquhart, G.M.
,
[The association between samorin chemoprophylaxis and immune responses in cattle under experimental metacyclic Trypanosoma congolense challenge]
,
The association between samorin chemoprophylaxis and immune responses in cattle under experimental metacyclic Trypanosoma congolense challenge