Descubre y comparte nuestro conocimiento público

Se han encontrado 209 recursos

Resultados de búsqueda

Inestrosa Cantín, Nibaldo.[Acetylcholinesterase Is a Senile Plaque Component That Prometes Assembly of Amyloid B-Peptide Into Alzheimer's Filaments]Acetylcholinesterase Is a Senile Plaque Component That Prometes Assembly of Amyloid B-Peptide Into Alzheimer's Filaments

Cabeza, Carolina.Figueroa, Alicia.Lazo Jerez, Oscar Marcelo.Galleguillos, Carolina.Pissani Alvear, Claudia.Klein, Andrés.Inestrosa Cantín, Nibaldo.Álvarez, Alejandra R.Zanlungo Matsuhiro, Silvana.Bronfman C., Francisca.Gonzalez-Billault, Christian.[Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick Type C disease]Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick Type C disease

Tapia Rojas, Cheril Cecilia.Lindsay, Carolina B.Montecinos Oliva, Carla.Arrazola Tello, Macarena Soledad.Retamales, Rocio M.Inestrosa Cantín, Nibaldo.Bunout, DanielHirsch, Sandra.[Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice]Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice

Abstract Background Septal cholinergic neurons account for most of the cholinergic innervations of the hippocampus, playing a key role in the regulation of hippocampal synaptic activity. Disruption of the septo-hippocampal pathway by an experimental ...


Lazo Jerez, Oscar Marcelo.Mauna, Jocelyn C.Pissani Alvear, Claudia.Inestrosa Cantín, Nibaldo.Bronfman C., Francisca.[Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons]Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons

Abstract Background In the adult central nervous system (CNS), Wnt signaling regulates dendritic structure and synaptic plasticity. The Wnt signaling pathway can be divided into the canonical (β-catenin-dependent) and non-canonical pathways. In the c...


Ríos Leal, Juvenal Antonio.Godoy Zeballos, Juan Alejandro.Inestrosa Cantín, Nibaldo.[Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis]Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis

Abstract Background In the adult hippocampus new neurons are continuously generated from neural stem cells (NSCs) present at the subgranular zone of the dentate gyrus. This process is controlled by Wnt signaling, which plays a complex role in regulat...


Inestrosa Cantín, Nibaldo.Mardones, Muriel D.Andaur, Gabriela A.Varas-Godoy, Manuel.Henriquez, Jenny F.Salech, Felipe.Behrens, María I.Couve, Andrés.Varela-Nallar, Lorena.[Frizzled-1 receptor regulates adult hippocampal neurogenesis]Frizzled-1 receptor regulates adult hippocampal neurogenesis

Fuentealba Alday, Rodrigo Esteban.Barría, María I.Lee, JiyeonCam, JudyAraya Olave, Claudia Andrea.Escudero Izquierdo, Claudia Andrea.Inestrosa Cantín, Nibaldo.Bronfman C., Francisca.Bu, GuojunMarzolo Canales, María Paz.[ApoER2 expression increases AB production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of Y-secretase activity]ApoER2 expression increases AB production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of Y-secretase activity

Abstract The presence of amyloid-β (Aβ) deposits in selected brain regions is a hallmark of Alzheimer's disease (AD). The amyloid deposits have "chaperone molecules" which play critical roles in amyloid formation and toxicity. We report here that treatment of rat hippocampal neurons...


Dinamarca Ceballos, Margarita Constanza.Sagal, Juan P.Quintanilla Gómez, Rodrigo Arthur.Godoy, Juan A.Arrázola, Macarena SInestrosa Cantín, Nibaldo.[Amyloid-B-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the AB peptide. Implications for the pathogenesis of Alzheimer's disease]Amyloid-B-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the AB peptide. Implications for the pathogenesis of Alzheimer's disease

Abstract Background Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ oligomers block hippocampal long-term potentiation (LTP) and impair rodent spati...


Cerpa Nebott, Waldo Francisco.Farías Galdames, Ginny Cheryl.Godoy Zeballos, Juan Alejandro.Inestrosa Cantín, Nibaldo.Fuenzalida, Marco.Bonansco, Christian.[Wnt-5aoccludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons]Wnt-5aoccludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons

Montecinos Oliva, Carla Javiera.Schueller, Andreas Peter.Inestrosa Cantín, Nibaldo.[Tetrahydrohyperforin: a neuroprotective modified natural compound against Alzheimer's disease]Tetrahydrohyperforin: a neuroprotective modified natural compound against Alzheimer's disease

Selecciona los documentos para visualizarlos

Nombre del archivo Ver recurso