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This paper reports the results of a genome-wide search for quantitative trait loci (QTL) influencing immunological responses to infection with the gastro-intestinal nematode parasite Heligmosomoides polygyrus in an F2 population created by crossing the resistant SWR and the susceptible CBA inbr...


Menge, D.M.Behnke, J.M.Lowe, A.Gibson, John P.Iraqi, F.A.Baker, R.L.Wakelin, D.[Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice]Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice

The host-protective immune response to infection with gastrointestinal (GI) nematodes involves a range of interacting processes that begin with recognition of the parasite's antigens and culminate in an inflammatory reaction in the intestinal mucosa. Precisely which immune effectors are responsib...


Behnke, J.M.Iraqi, F.A.Menge, D.Baker, R.L.Gibson, John P.Wakelin, D.[Chasing the genes that control resistance to gastrointestinal nematodes]Chasing the genes that control resistance to gastrointestinal nematodes

Since the publication of the mouse genome, attention has focused on the strains that were selected for sequencing. In this paper we report the results of experiments that characterized the response to infection with the murine gastrointestinal nematode Heligmosomoides polygyrus of eight new strai...


Behnke, J.M.Mugambi, J.M.M.Clifford, S.Iraqi, F.A.Baker, R.L.Gibson, John P.Wakelin, D.[Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project]Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project

Quantitative trait loci (QTL) associated with resistance to an intestinal worm in a well-defined murine model are described. These have been identified in an F(2) population derived from resistant (SWR) and susceptible (CBA) parental mouse strains infected with the gastro-intestinal nematode par...


Iraqi, F.A.Behnke, J.M.Menge, D.M.Lowe, A.M.Teale, A.J.Gibson, John P.Baker, L.R.Wakelin, D.R.[Chromosomal regions controlling resistance to gastro-intestinal nematode infections in mice]Chromosomal regions controlling resistance to gastro-intestinal nematode infections in mice

Breeds of cattle, sheep and goats have been identified which are genetically resistant and/or tolerant to gastro-intestinal nematode parasites. Mapping and cloning of resistant genes will facilitate Development of new breeds of livestock, which combine this important disease resistance trait with...


Iraqi, F.A.Menge, D.Gibson, P.J.Baker, R.L.Wakelin, D.Behnke, J.M.Lowe, A.Teale, A.J.Wakelin, D.[Mapping chromosomal regions controlling resistance to gastro-intestinal worms in mice. Poster presentation]Mapping chromosomal regions controlling resistance to gastro-intestinal worms in mice. Poster presentation
Behnke, J.Iraqi, F.A.Menge, D.Lowe, A.Teale, A.J.Gibson, P.J.Baker, R.L.Wakelin, D.[Mapping chromosomal regions controlling resistance to gastro-intestinal worms in mice]Mapping chromosomal regions controlling resistance to gastro-intestinal worms in mice

Genome-wide quantitative trait locus (QTL) mapping was used to evaluate the genetic basis of resistance to Helgmosomides polygyrus in an F2 cross of SWR and CBA mouse strains that are resistant and susceptible, respectively, to infection. 25 significant QTL affecting at least one of the resistanc...


Menge, D.M.Behnke, J.M.Iraqi, F.A.Lowe, A.Teale, A.J.Gibson, John P.Wakelin, D.Baker, R.L.[Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice]Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice
Iraqi, F.A.Hernández Valladares, M.Ogugo, M.Njoroge, T.Nthale, J.King, R.Naessens, JanGibson, P.J.Musoke, A.J.Ole-MoiYoi, O.K.[Fine mapping of quantitative trait loci resistance to malaria using advanced intercross lines of mice]Fine mapping of quantitative trait loci resistance to malaria using advanced intercross lines of mice
Hernández Valladares, M.Ogugo, M.Njoroge, T.Nthale, J.Naessens, JanGibson, P.J.Musoke, A.J.Ole-MoiYoi, O.K.Iraqi, F.A.[High resolution mapping of the quantitative trait loci resistance to malaria using advanced intercross lines of mice: A step towards cloning the corresponding genes]High resolution mapping of the quantitative trait loci resistance to malaria using advanced intercross lines of mice: A step towards cloning the corresponding genes
Noyes, H.A.Wu, J.Broadhead, A.Kemp, Stephen J.Iraqi, F.A.[Identifying Trypanosoma congolense resistance genes by positional cloning]Identifying Trypanosoma congolense resistance genes by positional cloning

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