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C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-α) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-α genes was correlated with the capacity to control parasitaemia and with survi...


Naessens, JanKitani, H.Momotani, E.Sekikawa, K.Nthale, J.M.Iraqi, F.A.[Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response]Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response

Trypanosomosis is the most economically important disease constraint to livestock productivity in Africa. A number of trypanotolerant cattle breeds are found in West Africa, and identification of the genes conferring trypanotolerance could lead to effective means of genetic selection for trypanot...


Ng'ang'a, J.K.Soller, M.Iraqi, F.A.[High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele]High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele

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