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Journal Article 1998

Autor: Iraqi, F.A. Teale, A.J.

The tumor necrosis factor (TNF) locus comprises the tandemly arranged genes coding for Tnfa (cachectin) and Tnfb (lymphotoxin-alpha) (Semon et al 1987). In mice, the TNF locus is located on chromosome 17 (MMU17) in the major histocompatibility complex (MHC) region. Tnfa and soluble lymphotoxin al...

Enlace original: https://cgspace.cgiar.org/handle/10568/32944

Investigación en Agricultura
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Iraqi, F.A. ,  Teale, A.J. ,  [Polymorphism in the microsatellite located in the promoters of the Tnfa and Tnfb genes of different mouse strains] ,  Polymorphism in the microsatellite located in the promoters of the Tnfa and Tnfb genes of different mouse strains
Journal Article 1999

Autor: Iraqi, F.A. Teale, A.J.

In view of the Tnfa gene location within the major histocompatibility (MHC) region and reports of its importance in disease protection activity, this paper examines the TNF a genes of a number of different mouse strains which were known to be of different disease response phenotypes. Twelve inbre...

Enlace original: https://cgspace.cgiar.org/handle/10568/32943

Investigación en Agricultura
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Iraqi, F.A. ,  Teale, A.J. ,  [Polymorphisms, in the Tnfa gene of different inbred mouse strains] ,  Polymorphisms, in the Tnfa gene of different inbred mouse strains
Journal Article 2008

Autor: Koudande, O.D. Thomson, P.C. Bovenhuis, H. Iraqi, F.A. Gibson, John P. Arendonk, Johan A.M. van

A marker-assisted introgression (MAI) experiment was conducted to transfer trypanotolerance quantitative trait loci (QTL) from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. The objective was to assess the effect of three previously identified chromosomal regions on mouse chro...

Enlace original: https://cgspace.cgiar.org/handle/10568/32934

Investigación en Agricultura
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Koudande, O.D. ,  Thomson, P.C. ,  Bovenhuis, H. ,  Iraqi, F.A. ,  Gibson, John P. ,  Arendonk, Johan A.M. van ,  [Biphasic survival analysis of trypanotolerance QTL in mice] ,  Biphasic survival analysis of trypanotolerance QTL in mice
Journal Article 2004

Autor: Hernández Valladares, M. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A.

A number of linkage studies in human populations have identified a locus ( pfbi) on Chromosome 5q31-q33 controlling Plasmodiun falciparum blood infection levels. This region contains numerous candidate genes encoding immunological molecules such as cytokines, growth factors and growth-factor rec...

Enlace original: https://cgspace.cgiar.org/handle/10568/32938

Investigación en Agricultura
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Hernández Valladares, M. ,  Rihet, P. ,  Ole-MoiYoi, O.K. ,  Iraqi, F.A. ,  [Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human chromosome 5q31-q33] ,  Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human chromosome 5q31-q33
Journal Article 2005

Autor: Foote, S.J. Iraqi, F.A. Kemp, Stephen J.

Malaria and trypanosomiasis are vector-borne protozoal diseases which disproportionately affect the poor. Both give rise to immense human suffering; malaria exerts its effect directly on human health, while trypanosomiasis causes damage largely though its effect on the health and productivity of ...

Enlace original: https://cgspace.cgiar.org/handle/10568/35256

Investigación en Agricultura
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Foote, S.J. ,  Iraqi, F.A. ,  Kemp, Stephen J. ,  [Controlling malaria and African trypanosomiasis: The role of the mouse] ,  Controlling malaria and African trypanosomiasis: The role of the mouse
Journal Article 2002-04-15

Autor: Kitani, H. Black, S.J. Nakamura, Y. Naessens, Jan Murphy, N. Yokomizo, Y. Gibson, John P. Iraqi, F.A.

Mice whose tumor necrosis factor alpha (TNF-) genes were disrupted developed higher levels of parasitemia than wild-type mice following infection with Trypanosoma congolense IL1180 or T. brucei brucei GUTat3.1, confirming the results of earlier studies. To determine whether TNF- directly affects ...

Enlace original: https://cgspace.cgiar.org/handle/10568/1540

Investigación en Agricultura
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Kitani, H. ,  Black, S.J. ,  Nakamura, Y. ,  Naessens, Jan ,  Murphy, N. ,  Yokomizo, Y. ,  Gibson, John P. ,  Iraqi, F.A. ,  [Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures] ,  Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures
Journal Article 2000-08-15

Autor: Iraqi, F.A. Clapcott, S.J. Kumari, P. Haley, C.S. Kemp, Stephen J. Teale, A.J.

We have previously reported the results of genome-wide searches in two murine F2 populations for QTLs that influence survival following Trypanosoma congolense infection. Three loci, Tir1, Tir2, and Tir3, were identified and mapped to mouse Chromosomes (Chrs) 17, 5, and 1 respectively, with confid...

Enlace original: https://cgspace.cgiar.org/handle/10568/1558

Investigación en Agricultura
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Iraqi, F.A. ,  Clapcott, S.J. ,  Kumari, P. ,  Haley, C.S. ,  Kemp, Stephen J. ,  Teale, A.J. ,  [Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines] ,  Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines
Journal Article 2007

Autor: Kazuhiro, Y. Agaba, Morris Iraqi, F.A. Naessens, Jan

It is known that different breeds of cattle display differential susceptibilities to Trypanosome congolense infections, and that N'Dama cattle remain more productive after infection than Boran cattle which are more susceptible to T. congolense. Macrophages from both breeds were cultured in vitro ...

Enlace original: https://cgspace.cgiar.org/handle/10568/1543

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Kazuhiro, Y. ,  Agaba, Morris ,  Iraqi, F.A. ,  Naessens, Jan ,  [Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense] ,  Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense
Journal Article 2006-12-15

Autor: Hernández Valladares, M. Naessens, Jan Musoke, A.J. Sekikawa, K. Rihet, P. Ole-MoiYoi, O.K. Busher, P. Iraqi, F.A.

Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival...

Enlace original: https://cgspace.cgiar.org/handle/10568/1400

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Musoke, A.J. ,  Sekikawa, K. ,  Rihet, P. ,  Ole-MoiYoi, O.K. ,  Busher, P. ,  Iraqi, F.A. ,  [Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ] ,  Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ
Journal Article 2009-09-08

Autor: Rathkolb, B. Noyes, H.A. Brass, A. Dark, P. Fuchs, H. Gailus-Durner, V. Gibson, John P. Angelis, M.H. de Ogugo, M. Iraqi, F.A. Kemp, Stephen J. Naessens, Jan Pope, M.E. Wolf, E. Agaba, Morris

Trypanosoma congolense is a protozoan parasite that causes severe diseases in livestock. Three major quantative trait loci (QTL), Tir1, Tir2, and Tir3, control the survival time of mice after infection with T. congolense. Congenic mice carrying the C57BL/6 resistance alleles on the A/J background...

Enlace original: https://cgspace.cgiar.org/handle/10568/46

Investigación en Agricultura
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Rathkolb, B. ,  Noyes, H.A. ,  Brass, A. ,  Dark, P. ,  Fuchs, H. ,  Gailus-Durner, V. ,  Gibson, John P. ,  Angelis, M.H. de ,  Ogugo, M. ,  Iraqi, F.A. ,  Kemp, Stephen J. ,  Naessens, Jan ,  Pope, M.E. ,  Wolf, E. ,  Agaba, Morris ,  [Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection] ,  Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection

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