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Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...


Kemp, Stephen J.Iraqi, F.A.Darvasi, A.Soller, M.Teale, A.J.[Localization of genes controlling resistance to trypanosomiasis in mice]Localization of genes controlling resistance to trypanosomiasis in mice
Autor: Iraqi, F.A.

High-resolution mapping of quantitative trait loci (QTLs) is an essential step towards positional cloning and identification of the corresponding genes. Most QTL detection and mapping studies in mice have been carried out using F2 intercross and backcross populations. As a consequence of the limi...


Iraqi, F.A.[Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes]Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes

A marker-assisted introgression (MAI) experiment was conducted to use genetic markers to transfer each of the three trypanotolerance QTL from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. We used a backcross strategy that consisted of selecting two lines, each carrying two of...


Koudande, O.D.Arendonk, Johan A.M. vanIraqi, F.A.[Marker-assisted introgression of trypanotolerance QTL in mice]Marker-assisted introgression of trypanotolerance QTL in mice

Breeds of cattle, sheep and goats have been identified which are genetically resistant and/or tolerant to gastro-intestinal nematode parasites. Mapping and cloning of resistant genes will facilitate Development of new breeds of livestock, which combine this important disease resistance trait with...


Iraqi, F.A.Menge, D.Gibson, P.J.Baker, R.L.Wakelin, D.Behnke, J.M.Lowe, A.Teale, A.J.Wakelin, D.[Mapping chromosomal regions controlling resistance to gastro-intestinal worms in mice. Poster presentation]Mapping chromosomal regions controlling resistance to gastro-intestinal worms in mice. Poster presentation
Behnke, J.Iraqi, F.A.Menge, D.Lowe, A.Teale, A.J.Gibson, P.J.Baker, R.L.Wakelin, D.[Mapping chromosomal regions controlling resistance to gastro-intestinal worms in mice]Mapping chromosomal regions controlling resistance to gastro-intestinal worms in mice

Genome-wide quantitative trait locus (QTL) mapping was used to evaluate the genetic basis of resistance to Helgmosomides polygyrus in an F2 cross of SWR and CBA mouse strains that are resistant and susceptible, respectively, to infection. 25 significant QTL affecting at least one of the resistanc...


Menge, D.M.Behnke, J.M.Iraqi, F.A.Lowe, A.Teale, A.J.Gibson, John P.Wakelin, D.Baker, R.L.[Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice]Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice

C57BL/6J mice are relatively resistant to trypanosomosis compared to BALB/c or A/J mice. Bloodstream trypanosomes are partly dependent on the host for lipid supply and the plasma lipid levels differ between resistant and susceptible mice. Furthermore, genes controlling plasma lipid levels are dif...


Hassan, M.Agaba, MorrisBulimo, WallaceNoyes, H.Brass, A.Hinsley, T.Iraqi, F.A.Kemp, Stephen J.[Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis]Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis
Iraqi, F.A.Hernández Valladares, M.Ogugo, M.Njoroge, T.Nthale, J.King, R.Naessens, JanGibson, P.J.Musoke, A.J.Ole-MoiYoi, O.K.[Fine mapping of quantitative trait loci resistance to malaria using advanced intercross lines of mice]Fine mapping of quantitative trait loci resistance to malaria using advanced intercross lines of mice
Hernández Valladares, M.Ogugo, M.Njoroge, T.Nthale, J.Naessens, JanGibson, P.J.Musoke, A.J.Ole-MoiYoi, O.K.Iraqi, F.A.[High resolution mapping of the quantitative trait loci resistance to malaria using advanced intercross lines of mice: A step towards cloning the corresponding genes]High resolution mapping of the quantitative trait loci resistance to malaria using advanced intercross lines of mice: A step towards cloning the corresponding genes
Noyes, H.A.Wu, J.Broadhead, A.Kemp, Stephen J.Iraqi, F.A.[Identifying Trypanosoma congolense resistance genes by positional cloning]Identifying Trypanosoma congolense resistance genes by positional cloning

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