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Journal Article 2007

Autor: Hernández Valladares, M. Naessens, Jan Iraqi, F.A.

Gene-knockout mice have been extensively used in the study of several malaria-induced pathologies. Some investigators believe that the deficient, infected mice mimic disease aspects produced in the absence of the target gene, but others believe that the deficient mice models mainly explain the ef...

Enlace original: https://cgspace.cgiar.org/handle/10568/33188

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Iraqi, F.A. ,  [Gene-knockout mice in malaria research: Useful or misleading?] ,  Gene-knockout mice in malaria research: Useful or misleading?
Journal Article 2005

Autor: Hernández Valladares, M. Naessens, Jan Iraqi, F.A.

Murine models have proved to be excellent tools in the support of studies of the human genetic bases of malaria resistance and have enabled the mapping of 12 resistance loci, eight of them controlling parasitic levels and four controlling cerebral malaria. Further studies using this method have i...

Enlace original: https://cgspace.cgiar.org/handle/10568/33187

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Iraqi, F.A. ,  [Genetic resistance to malaria in mouse models] ,  Genetic resistance to malaria in mouse models
Journal Article 2001

Autor: Iraqi, F.A. Sekikawa, K. Rowlands, G.J. Teale, A.J.

The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...

Enlace original: https://cgspace.cgiar.org/handle/10568/33087

Investigación en Agricultura
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Iraqi, F.A. ,  Sekikawa, K. ,  Rowlands, G.J. ,  Teale, A.J. ,  [Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection] ,  Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection
Journal Article 2006

Autor: Behnke, J.M. Mugambi, J.M.M. Clifford, S. Iraqi, F.A. Baker, R.L. Gibson, John P. Wakelin, D.

Since the publication of the mouse genome, attention has focused on the strains that were selected for sequencing. In this paper we report the results of experiments that characterized the response to infection with the murine gastrointestinal nematode Heligmosomoides polygyrus of eight new strai...

Enlace original: https://cgspace.cgiar.org/handle/10568/33090

Investigación en Agricultura
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Behnke, J.M. ,  Mugambi, J.M.M. ,  Clifford, S. ,  Iraqi, F.A. ,  Baker, R.L. ,  Gibson, John P. ,  Wakelin, D. ,  [Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project] ,  Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project
Journal Article 1997

Autor: Kemp, Stephen J. Iraqi, F.A. Darvasi, A. Soller, M. Teale, A.J.

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...

Enlace original: https://cgspace.cgiar.org/handle/10568/33074

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Kemp, Stephen J. ,  Iraqi, F.A. ,  Darvasi, A. ,  Soller, M. ,  Teale, A.J. ,  [Localization of genes controlling resistance to trypanosomiasis in mice] ,  Localization of genes controlling resistance to trypanosomiasis in mice
Journal Article 2003

Autor: Wang, M. Lemon, W.J. Liu, G. Wang, Y. Iraqi, F.A. Malkinson, A.M. You, M.

In the present study, we used newly developed F11 generation mouse advanced intercross lines (AIL) to fine map Pas1–3 quantitative trait loci (QTL). The (A/J x C57BL/6) F11 AIL mouse population was created by crossing lung tumor-resistant C57BL/6 mice with lung tumor-susceptible A/J mice. By se...

Enlace original: https://cgspace.cgiar.org/handle/10568/32868

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Wang, M. ,  Lemon, W.J. ,  Liu, G. ,  Wang, Y. ,  Iraqi, F.A. ,  Malkinson, A.M. ,  You, M. ,  [Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines] ,  Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines
Journal Article 2000

Autor: Iraqi, F.A.

High-resolution mapping of quantitative trait loci (QTLs) is an essential step towards positional cloning and identification of the corresponding genes. Most QTL detection and mapping studies in mice have been carried out using F2 intercross and backcross populations. As a consequence of the limi...

Enlace original: https://cgspace.cgiar.org/handle/10568/28577

Investigación en Agricultura
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Iraqi, F.A. ,  [Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes] ,  Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes
Journal Article 2003

Autor: Iraqi, F.A. Behnke, J.M. Menge, D.M. Lowe, A.M. Teale, A.J. Gibson, John P. Baker, L.R. Wakelin, D.R.

Quantitative trait loci (QTL) associated with resistance to an intestinal worm in a well-defined murine model are described. These have been identified in an F(2) population derived from resistant (SWR) and susceptible (CBA) parental mouse strains infected with the gastro-intestinal nematode par...

Enlace original: https://cgspace.cgiar.org/handle/10568/29203

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Iraqi, F.A. ,  Behnke, J.M. ,  Menge, D.M. ,  Lowe, A.M. ,  Teale, A.J. ,  Gibson, John P. ,  Baker, L.R. ,  Wakelin, D.R. ,  [Chromosomal regions controlling resistance to gastro-intestinal nematode infections in mice] ,  Chromosomal regions controlling resistance to gastro-intestinal nematode infections in mice
Journal Article 2004

Autor: Hernández Valladares, M. Naessens, Jan Gibson, John P. Musoke, A.J. Nagda, S.M. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A.

We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatel...

Enlace original: https://cgspace.cgiar.org/handle/10568/29204

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Gibson, John P. ,  Musoke, A.J. ,  Nagda, S.M. ,  Rihet, P. ,  Ole-MoiYoi, O.K. ,  Iraqi, F.A. ,  [Confirmation and dissection of QTL controlling resistance to malaria in mice] ,  Confirmation and dissection of QTL controlling resistance to malaria in mice
Journal Article 2005

Autor: Koudande, O.D. Arendonk, Johan A.M. van Iraqi, F.A.

A marker-assisted introgression (MAI) experiment was conducted to use genetic markers to transfer each of the three trypanotolerance QTL from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. We used a backcross strategy that consisted of selecting two lines, each carrying two of...

Enlace original: https://cgspace.cgiar.org/handle/10568/29205

Investigación en Agricultura
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Koudande, O.D. ,  Arendonk, Johan A.M. van ,  Iraqi, F.A. ,  [Marker-assisted introgression of trypanotolerance QTL in mice] ,  Marker-assisted introgression of trypanotolerance QTL in mice

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