High-resolution mapping of quantitative trait loci (QTLs) is an essential step towards positional cloning and identification of the corresponding genes. Most QTL detection and mapping studies in mice have been carried out using F2 intercross and backcross populations. As a consequence of the limi...
Iraqi, F.A.
,
[Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes]
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Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes
A marker-assisted introgression (MAI) experiment was conducted to use genetic markers to transfer each of the three trypanotolerance QTL from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. We used a backcross strategy that consisted of selecting two lines, each carrying two of...
Koudande, O.D.
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Arendonk, Johan A.M. van
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Iraqi, F.A.
,
[Marker-assisted introgression of trypanotolerance QTL in mice]
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Marker-assisted introgression of trypanotolerance QTL in mice
C57BL/6J mice are relatively resistant to trypanosomosis compared to BALB/c or A/J mice. Bloodstream trypanosomes are partly dependent on the host for lipid supply and the plasma lipid levels differ between resistant and susceptible mice. Furthermore, genes controlling plasma lipid levels are dif...
Hassan, M.
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Agaba, Morris
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Bulimo, Wallace
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Noyes, H.
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Brass, A.
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Hinsley, T.
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Iraqi, F.A.
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Kemp, Stephen J.
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[Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis]
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Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis
Ng'ang'a, J.
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Gibson, John P.
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Imbuga, J.
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Kemp, Stephen J.
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Iraqi, F.A.
,
[Towards fine mapping trypanosomiasis resistance QTL Tir 2 and 3 using F12 Tir1 depleted advanced intercross line population. Abstract]
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Towards fine mapping trypanosomiasis resistance QTL Tir 2 and 3 using F12 Tir1 depleted advanced intercross line population. Abstract
The cartography in the high resolution of quantitative locus of character (QTL) is an important step towards the positional cloning or the positional identification of candidate genes. Recently, the use of descendants at the advanced inter-junction has been described for the dissection and the pr...
Iraqi, F.A.
,
Kemp, Stephen J.
,
Teale, A.J.
,
[Towards identification and cloning of the trypanotolerance genes in mouse]
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Towards identification and cloning of the trypanotolerance genes in mouse
Macleod, A.K.
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Iraqi, F.A.
,
Haley, C.S.
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Gibson, John P.
,
[Using the false discovery rate in the detection of QTL for trypanosomiasis resistance in mice]
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Using the false discovery rate in the detection of QTL for trypanosomiasis resistance in mice
Kierstein, S.
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Noyes, H.A.
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Nakamura, Y.
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Naessens, Jan
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Kemp, Stephen J.
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Iraqi, F.A.
,
Gibson, John P.
,
[Gene expression profiling of resistance and susceptible mice infected with Trypanosoma congolense using microarrays. Abstract]
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Gene expression profiling of resistance and susceptible mice infected with Trypanosoma congolense using microarrays. Abstract
Nakamura, Y.
,
Tsuchiya, Y.
,
Naessens, Jan
,
Gibson, John P.
,
Iraqi, F.A.
,
[Glucocorticoid responses to Trypanosoma congolense infection in susceptible and resistance mouse strains. Abstract]
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Glucocorticoid responses to Trypanosoma congolense infection in susceptible and resistance mouse strains. Abstract
Ng'ang'a, J.
,
Iraqi, F.A.
,
[Characterization of trypanosomosis resistance locus Tir2 in mice. Abstract]
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Characterization of trypanosomosis resistance locus Tir2 in mice. Abstract