Certain breeds of domestic ruminants show remarkable resistance to the effects of African trypano-somosis. Unlike susceptible animals, trypanotolerant animals control parasitemia and do not show severe anaemia or production loss. Identification of trypanotolerance genes in cattle is hampered by c...
Trypanosoma congolense are extracellular protozoan parasites of the blood stream of artiodactyls and are one of the main constraints on cattle production in Africa. In cattle, anaemia is the key feature of disease and persists after parasitaemia has declined to low or undetectable levels, but tre...
Noyes, H.A.
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Alimohammadian, M.H.
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Agaba, Morris
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Brass, A.
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Fuchs, H.
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Gailus-Durner, V.
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Hulme, H.
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Iraqi, F.A.
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Kemp, Stephen J.
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Rathkolb, B.
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Wolf, E.
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Angelis, M.H. de
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Roshandel, D.
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Naessens, Jan
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[Mechanisms controlling anaemia in Trypanosoma congolense infected mice]
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Mechanisms controlling anaemia in Trypanosoma congolense infected mice
To optimize designs to implement marker-assisted introgression programs aiming to introgress three unlinked quantitative trait loci (QTL), the present paper studies different alternatives versus a traditional backcross or intercross phase. Four alternative backcross strategies appear to be more a...
Iraqi, F.A.
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Kemp, Stephen J.
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Teale, A.J.
,
[Fine mapping of trypanosomiasis resistance QTLs in mice using advanced intercross lines]
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Fine mapping of trypanosomiasis resistance QTLs in mice using advanced intercross lines
The heat shock protein (HSP) 70.1 gene lies on mouse chromosome 17 among the candidates for Tir1, the major quantitative trait locus associated with response to Trypanosoma congolense infection. To evaluate whether the HSP70.1 gene is involved in the response, we compared the susceptibility of HS...
Nakamura, Y.
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Naessens, Jan
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Takata, M.
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Taniguchi, T.
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Sekikawa, K.
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Gibson, John P.
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Iraqi, F.A.
,
[Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection]
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Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection
Tumor necrosis factor-α (TNF-α) plays a role in the host’s defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can influence paras...
Kitani, H.
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Yagi, Y.
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Naessens, Jan
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Sekikawa, K.
,
Iraqi, F.A.
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[The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-α gene]
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The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-α gene
Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...
Kemp, Stephen J.
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Iraqi, F.A.
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Darvasi, A.
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Soller, M.
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Teale, A.J.
,
[Localisation of genes controlling resistance to trypanosomiasis in mice]
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Localisation of genes controlling resistance to trypanosomiasis in mice
Trypanosomosis is the most economically important disease constraint to livestock productivity in Africa. A number of trypanotolerant cattle breeds are found in West Africa, and identification of the genes conferring trypanotolerance could lead to effective means of genetic selection for trypanot...
Ng'ang'a, J.K.
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Soller, M.
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Iraqi, F.A.
,
[High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele]
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High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele
Synthetic antimicrobial 9-mer peptides (designated as peptides A and B) designed on the basis of insect defensins and their effects on the growth of African trypanosomes were examined using two isolates of Trypanosoma congolense, IL1180 and IL3338, and two isolates of Trypanosoma brucei brucei, I...
Kitani, H.
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Naessens, Jan
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Kubo, M.
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Nakamura, Y.
,
Iraqi, F.A.
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Gibson, John P.
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Yamakawa, M.
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[Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture]
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Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture