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Journal Article 2003

Autor: Menge, D.M. Behnke, J.M. Lowe, A. Gibson, John P. Iraqi, F.A. Baker, R.L. Wakelin, D.

This paper reports the results of a genome-wide search for quantitative trait loci (QTL) influencing immunological responses to infection with the gastro-intestinal nematode parasite Heligmosomoides polygyrus in an F2 population created by crossing the resistant SWR and the susceptible CBA inbr...

Enlace original: https://cgspace.cgiar.org/handle/10568/33089

Investigación en Agricultura
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Menge, D.M. ,  Behnke, J.M. ,  Lowe, A. ,  Gibson, John P. ,  Iraqi, F.A. ,  Baker, R.L. ,  Wakelin, D. ,  [Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice] ,  Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice
Journal Article 2007

Autor: Hernández Valladares, M. Naessens, Jan Iraqi, F.A.

Gene-knockout mice have been extensively used in the study of several malaria-induced pathologies. Some investigators believe that the deficient, infected mice mimic disease aspects produced in the absence of the target gene, but others believe that the deficient mice models mainly explain the ef...

Enlace original: https://cgspace.cgiar.org/handle/10568/33188

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Iraqi, F.A. ,  [Gene-knockout mice in malaria research: Useful or misleading?] ,  Gene-knockout mice in malaria research: Useful or misleading?
Journal Article 2005

Autor: Hernández Valladares, M. Naessens, Jan Iraqi, F.A.

Murine models have proved to be excellent tools in the support of studies of the human genetic bases of malaria resistance and have enabled the mapping of 12 resistance loci, eight of them controlling parasitic levels and four controlling cerebral malaria. Further studies using this method have i...

Enlace original: https://cgspace.cgiar.org/handle/10568/33187

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Iraqi, F.A. ,  [Genetic resistance to malaria in mouse models] ,  Genetic resistance to malaria in mouse models
Journal Article 2003

Autor: Behnke, J.M. Iraqi, F.A. Menge, D. Baker, R.L. Gibson, John P. Wakelin, D.

The host-protective immune response to infection with gastrointestinal (GI) nematodes involves a range of interacting processes that begin with recognition of the parasite's antigens and culminate in an inflammatory reaction in the intestinal mucosa. Precisely which immune effectors are responsib...

Enlace original: https://cgspace.cgiar.org/handle/10568/33007

Investigación en Agricultura
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Behnke, J.M. ,  Iraqi, F.A. ,  Menge, D. ,  Baker, R.L. ,  Gibson, John P. ,  Wakelin, D. ,  [Chasing the genes that control resistance to gastrointestinal nematodes] ,  Chasing the genes that control resistance to gastrointestinal nematodes
Journal Article 2001

Autor: Iraqi, F.A. Sekikawa, K. Rowlands, G.J. Teale, A.J.

The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...

Enlace original: https://cgspace.cgiar.org/handle/10568/33087

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Iraqi, F.A. ,  Sekikawa, K. ,  Rowlands, G.J. ,  Teale, A.J. ,  [Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection] ,  Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection
Journal Article 2010-02-15

Autor: Behnke, J.M. Menge, D.M. Nagda, S.M. Noyes, H. Iraqi, F.A. Kemp, Stephen J. Mugambi, R.J.M. Baker, R.L. Wakelin, D. Gibson, John P.

A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens...

Enlace original: https://cgspace.cgiar.org/handle/10568/358

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Behnke, J.M. ,  Menge, D.M. ,  Nagda, S.M. ,  Noyes, H. ,  Iraqi, F.A. ,  Kemp, Stephen J. ,  Mugambi, R.J.M. ,  Baker, R.L. ,  Wakelin, D. ,  Gibson, John P. ,  [Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice] ,  Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice
Journal Article 2006-06-15

Autor: Behnke, J.M. Iraqi, F.A. Mugambi, J.M.M. Clifford, S. Nagda, S.M. Wakelin, D. Kemp, Stephen J. Leyden, B. Gibson, John P.

Fine mapping of quantitative trait loci (QTL) associated with resistance to the gastrointestinal parasite Heligmosomoides polygyrus was achieved on F6/F7 offspring (1076 mice) from resistant (SWR) and susceptible (CBA) mouse strains by selective genotyping (top and bottom 20% selected on total wo...

Enlace original: https://cgspace.cgiar.org/handle/10568/1577

Investigación en Agricultura
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Behnke, J.M. ,  Iraqi, F.A. ,  Mugambi, J.M.M. ,  Clifford, S. ,  Nagda, S.M. ,  Wakelin, D. ,  Kemp, Stephen J. ,  Leyden, B. ,  Gibson, John P. ,  [High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice] ,  High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice
Journal Article 2006

Autor: Behnke, J.M. Mugambi, J.M.M. Clifford, S. Iraqi, F.A. Baker, R.L. Gibson, John P. Wakelin, D.

Since the publication of the mouse genome, attention has focused on the strains that were selected for sequencing. In this paper we report the results of experiments that characterized the response to infection with the murine gastrointestinal nematode Heligmosomoides polygyrus of eight new strai...

Enlace original: https://cgspace.cgiar.org/handle/10568/33090

Investigación en Agricultura
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Behnke, J.M. ,  Mugambi, J.M.M. ,  Clifford, S. ,  Iraqi, F.A. ,  Baker, R.L. ,  Gibson, John P. ,  Wakelin, D. ,  [Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project] ,  Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project
Journal Article 1997

Autor: Kemp, Stephen J. Iraqi, F.A. Darvasi, A. Soller, M. Teale, A.J.

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...

Enlace original: https://cgspace.cgiar.org/handle/10568/33074

Investigación en Agricultura
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Kemp, Stephen J. ,  Iraqi, F.A. ,  Darvasi, A. ,  Soller, M. ,  Teale, A.J. ,  [Localization of genes controlling resistance to trypanosomiasis in mice] ,  Localization of genes controlling resistance to trypanosomiasis in mice
Journal Article 2003

Autor: Wang, M. Lemon, W.J. Liu, G. Wang, Y. Iraqi, F.A. Malkinson, A.M. You, M.

In the present study, we used newly developed F11 generation mouse advanced intercross lines (AIL) to fine map Pas1–3 quantitative trait loci (QTL). The (A/J x C57BL/6) F11 AIL mouse population was created by crossing lung tumor-resistant C57BL/6 mice with lung tumor-susceptible A/J mice. By se...

Enlace original: https://cgspace.cgiar.org/handle/10568/32868

Investigación en Agricultura
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Wang, M. ,  Lemon, W.J. ,  Liu, G. ,  Wang, Y. ,  Iraqi, F.A. ,  Malkinson, A.M. ,  You, M. ,  [Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines] ,  Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines

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