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Journal Article 2003

Autor: Wang, M. Lemon, W.J. Liu, G. Wang, Y. Iraqi, F.A. Malkinson, A.M. You, M.

In the present study, we used newly developed F11 generation mouse advanced intercross lines (AIL) to fine map Pas1–3 quantitative trait loci (QTL). The (A/J x C57BL/6) F11 AIL mouse population was created by crossing lung tumor-resistant C57BL/6 mice with lung tumor-susceptible A/J mice. By se...

Enlace original: https://cgspace.cgiar.org/handle/10568/32868

Investigación en Agricultura
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Wang, M. ,  Lemon, W.J. ,  Liu, G. ,  Wang, Y. ,  Iraqi, F.A. ,  Malkinson, A.M. ,  You, M. ,  [Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines] ,  Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines
Journal Article 2010-11-09

Autor: Goodhead, I. Archibald, A.L. Amwayi, P. Brass, A. Gibson, John P. Hall, N. Hughes, Monica A. Limo, M.K.H. Iraqi, F.A. Kemp, Stephen J. Noyes, H.A.

African trypanosomes are protozoan parasites that cause “sleeping sickness” in humans and a similar disease in livestock. Trypanosomes also infect laboratory mice and three major quantitative trait loci (QTL) that regulate survival time after infection with T. congolense have been identified in t...

Enlace original: https://cgspace.cgiar.org/handle/10568/3500

Investigación en Agricultura
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Goodhead, I. ,  Archibald, A.L. ,  Amwayi, P. ,  Brass, A. ,  Gibson, John P. ,  Hall, N. ,  Hughes, Monica A. ,  Limo, M.K.H. ,  Iraqi, F.A. ,  Kemp, Stephen J. ,  Noyes, H.A. ,  [A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice] ,  A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice
Journal Article 2000

Autor: Iraqi, F.A.

High-resolution mapping of quantitative trait loci (QTLs) is an essential step towards positional cloning and identification of the corresponding genes. Most QTL detection and mapping studies in mice have been carried out using F2 intercross and backcross populations. As a consequence of the limi...

Enlace original: https://cgspace.cgiar.org/handle/10568/28577

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Iraqi, F.A. ,  [Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes] ,  Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes
Journal Article 2005

Autor: Flori, L. Delahaye, N.F. Iraqi, F.A. Hernández Valladares, M. Fumoux, F. Rihet, P.

We have previously obtained strong evidence for linkage of mild malaria attack to the MHC region, with a peak close to the tumor necrosis factor (TNF) gene. We screened, for polymorphisms, the entire TNF gene in the same sample of 34 families comprising 197 individuals living in a Plasmodium falc...

Enlace original: https://cgspace.cgiar.org/handle/10568/28659

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Flori, L. ,  Delahaye, N.F. ,  Iraqi, F.A. ,  Hernández Valladares, M. ,  Fumoux, F. ,  Rihet, P. ,  [TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso] ,  TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso
Journal Article 2003

Autor: Iraqi, F.A. Behnke, J.M. Menge, D.M. Lowe, A.M. Teale, A.J. Gibson, John P. Baker, L.R. Wakelin, D.R.

Quantitative trait loci (QTL) associated with resistance to an intestinal worm in a well-defined murine model are described. These have been identified in an F(2) population derived from resistant (SWR) and susceptible (CBA) parental mouse strains infected with the gastro-intestinal nematode par...

Enlace original: https://cgspace.cgiar.org/handle/10568/29203

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Iraqi, F.A. ,  Behnke, J.M. ,  Menge, D.M. ,  Lowe, A.M. ,  Teale, A.J. ,  Gibson, John P. ,  Baker, L.R. ,  Wakelin, D.R. ,  [Chromosomal regions controlling resistance to gastro-intestinal nematode infections in mice] ,  Chromosomal regions controlling resistance to gastro-intestinal nematode infections in mice
Journal Article 2004

Autor: Hernández Valladares, M. Naessens, Jan Gibson, John P. Musoke, A.J. Nagda, S.M. Rihet, P. Ole-MoiYoi, O.K. Iraqi, F.A.

We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatel...

Enlace original: https://cgspace.cgiar.org/handle/10568/29204

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Gibson, John P. ,  Musoke, A.J. ,  Nagda, S.M. ,  Rihet, P. ,  Ole-MoiYoi, O.K. ,  Iraqi, F.A. ,  [Confirmation and dissection of QTL controlling resistance to malaria in mice] ,  Confirmation and dissection of QTL controlling resistance to malaria in mice
Journal Article 2012-02-15

Autor: Silva, M.V.B. Sonstegard, T.S. Hanotte, Olivier H. Mugambi, J.M.M. García, J.F. Nagda, S.M. Gibson, John P. Iraqi, F.A. McClintock, A.E. Kemp, Stephen J. Boettcher, P.J. Malek, M. Tassell, C.P. van Baker, R.L.

A genome-wide scan for quantitative trait loci (QTL) affecting gastrointestinal nematode resistance in sheep was completed using a double backcross population derived from Red Maasai and Dorper ewes bred to F1 rams. This design provided an opportunity to map potentially unique genetic variation a...

Enlace original: https://cgspace.cgiar.org/handle/10568/72662

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Silva, M.V.B. ,  Sonstegard, T.S. ,  Hanotte, Olivier H. ,  Mugambi, J.M.M. ,  García, J.F. ,  Nagda, S.M. ,  Gibson, John P. ,  Iraqi, F.A. ,  McClintock, A.E. ,  Kemp, Stephen J. ,  Boettcher, P.J. ,  Malek, M. ,  Tassell, C.P. van ,  Baker, R.L. ,  [Identification of quantitative trait loci affecting resistance to gastrointestinal parasites in a double backcross population of Red Maasai and Dorper sheep] ,  Identification of quantitative trait loci affecting resistance to gastrointestinal parasites in a double backcross population of Red Maasai and Dorper sheep
Journal Article 2005

Autor: Koudande, O.D. Arendonk, Johan A.M. van Iraqi, F.A.

A marker-assisted introgression (MAI) experiment was conducted to use genetic markers to transfer each of the three trypanotolerance QTL from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. We used a backcross strategy that consisted of selecting two lines, each carrying two of...

Enlace original: https://cgspace.cgiar.org/handle/10568/29205

Investigación en Agricultura
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Koudande, O.D. ,  Arendonk, Johan A.M. van ,  Iraqi, F.A. ,  [Marker-assisted introgression of trypanotolerance QTL in mice] ,  Marker-assisted introgression of trypanotolerance QTL in mice
Journal Article 1998

Autor: Iraqi, F.A. Teale, A.J.

The tumor necrosis factor (TNF) locus comprises the tandemly arranged genes coding for Tnfa (cachectin)and Tnfb (lymphotoxin-alpha) (Semon et al. 1987). In mice, the TNF locus is located on chromosome 17 (MMU17) in the major histocompatibility complex (MHC)region. Tnfa and soluble lymphotoxin alp...

Enlace original: https://cgspace.cgiar.org/handle/10568/28701

Investigación en Agricultura
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Iraqi, F.A. ,  Teale, A.J. ,  [Polymorphisms in the TNFa but not in TNFb microsatellite and correlation with trypanosomiasis in mice] ,  Polymorphisms in the TNFa but not in TNFb microsatellite and correlation with trypanosomiasis in mice
Journal Article 2004

Autor: Kitani, H. Yagi, Y. Naessens, Jan Sekikawa, K. Iraqi, F.A.

Tumor necrosis factor-[alpha] (TNF-[alpha]) plays a role in the host's defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can inf...

Enlace original: https://cgspace.cgiar.org/handle/10568/29972

Investigación en Agricultura
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Kitani, H. ,  Yagi, Y. ,  Naessens, Jan ,  Sekikawa, K. ,  Iraqi, F.A. ,  [The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene] ,  The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene

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