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GI nematodes are most commonly controlled by chemotherapy. Anthelmintic efficacy is decreasing as drug resistance becomes widespread and other approaches are needed. Knowledge of protective immunity against GI parasites is important for the development of vaccine strategies. Success in this field...


Behnke, J.M.Lowe, A.Menge, M.Iraqi, F.A.Wakelin, D.[Mapping genes for resistance to gastrointestinal nematodes]Mapping genes for resistance to gastrointestinal nematodes

The development of cerebral malaria (CM) in mice with Plasmodium berghei ANKA infection is under genetic control. Brain gene-expression patterns were investigated in well-defined genetically CM-resistant (CM-R; BALB/c and DBA/2) and CM-susceptible (CM-S; C57BL/6 and CBA/J) mice by use of cDNA mic...


Delhaye, N.F.Coltel, N.Puthier, D.Flori, L.Houlgatte, R.Iraqi, F.A.Nguyen, C.Grau, G.E.Rihet, P.[Gene-expression profiling discriminates between cerebral malaria (CM) - susceptible mice and CM-resistant mice]Gene-expression profiling discriminates between cerebral malaria (CM) - susceptible mice and CM-resistant mice
Ng'ang'a, J.Iraqi, F.A.[Expression variation of TLR as candidate genes underlying trypanotolerance QTL in mice]Expression variation of TLR as candidate genes underlying trypanotolerance QTL in mice

The tumor necrosis factor (TNF) locus comprises the tandemly arranged genes coding for Tnfa (cachectin) and Tnfb (lymphotoxin-alpha) (Semon et al 1987). In mice, the TNF locus is located on chromosome 17 (MMU17) in the major histocompatibility complex (MHC) region. Tnfa and soluble lymphotoxin al...


Iraqi, F.A.Teale, A.J.[Polymorphism in the microsatellite located in the promoters of the Tnfa and Tnfb genes of different mouse strains]Polymorphism in the microsatellite located in the promoters of the Tnfa and Tnfb genes of different mouse strains

In view of the Tnfa gene location within the major histocompatibility (MHC) region and reports of its importance in disease protection activity, this paper examines the TNF a genes of a number of different mouse strains which were known to be of different disease response phenotypes. Twelve inbre...


Iraqi, F.A.Teale, A.J.[Polymorphisms, in the Tnfa gene of different inbred mouse strains]Polymorphisms, in the Tnfa gene of different inbred mouse strains

A marker-assisted introgression (MAI) experiment was conducted to transfer trypanotolerance quantitative trait loci (QTL) from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. The objective was to assess the effect of three previously identified chromosomal regions on mouse chro...


Koudande, O.D.Thomson, P.C.Bovenhuis, H.Iraqi, F.A.Gibson, John P.Arendonk, Johan A.M. van[Biphasic survival analysis of trypanotolerance QTL in mice]Biphasic survival analysis of trypanotolerance QTL in mice

A number of linkage studies in human populations have identified a locus ( pfbi) on Chromosome 5q31-q33 controlling Plasmodiun falciparum blood infection levels. This region contains numerous candidate genes encoding immunological molecules such as cytokines, growth factors and growth-factor rec...


Hernández Valladares, M.Rihet, P.Ole-MoiYoi, O.K.Iraqi, F.A.[Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human chromosome 5q31-q33]Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human chromosome 5q31-q33

Trypanosoma congolense is a protozoan parasite that causes severe diseases in livestock. Three major quantative trait loci (QTL), Tir1, Tir2, and Tir3, control the survival time of mice after infection with T. congolense. Congenic mice carrying the C57BL/6 resistance alleles on the A/J background...


Rathkolb, B.Noyes, H.A.Brass, A.Dark, P.Fuchs, H.Gailus-Durner, V.Gibson, John P.Angelis, M.H. deOgugo, M.Iraqi, F.A.Kemp, Stephen J.Naessens, JanPope, M.E.Wolf, E.Agaba, Morris[Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection]Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection

Trypanosoma congolense are extracellular protozoan parasites of the blood stream of artiodactyls and are one of the main constraints on cattle production in Africa. In cattle, anaemia is the key feature of disease and persists after parasitaemia has declined to low or undetectable levels, but tre...


Noyes, H.A.Alimohammadian, M.H.Agaba, MorrisBrass, A.Fuchs, H.Gailus-Durner, V.Hulme, H.Iraqi, F.A.Kemp, Stephen J.Rathkolb, B.Wolf, E.Angelis, M.H. deRoshandel, D.Naessens, Jan[Mechanisms controlling anaemia in Trypanosoma congolense infected mice]Mechanisms controlling anaemia in Trypanosoma congolense infected mice

This paper reports the results of a genome-wide search for quantitative trait loci (QTL) influencing immunological responses to infection with the gastro-intestinal nematode parasite Heligmosomoides polygyrus in an F2 population created by crossing the resistant SWR and the susceptible CBA inbr...


Menge, D.M.Behnke, J.M.Lowe, A.Gibson, John P.Iraqi, F.A.Baker, R.L.Wakelin, D.[Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice]Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice

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