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This paper undertakes an ex ante economic analysis of research on how resistance to trypanosomosis - a dominant livestock disease in Africa - can be maintained and enhanced while retaining and reinforcing characteristics of economic importance to farmers, and on how 'trypanotolerance' can be impa...


Falconi, C.A.Omamo, S.W.D'Ieteren, G.D.M.Iraqi, F.A.[An ex ante economic and policy analysis of research on genetic resistance to livestock disease: Trypanosomiasis in Africa]An ex ante economic and policy analysis of research on genetic resistance to livestock disease: Trypanosomiasis in Africa

Malaria and trypanosomiasis are vector-borne protozoal diseases which disproportionately affect the poor. Both give rise to immense human suffering; malaria exerts its effect directly on human health, while trypanosomiasis causes damage largely though its effect on the health and productivity of ...


Foote, S.J.Iraqi, F.A.Kemp, Stephen J.[Controlling malaria and African trypanosomiasis: The role of the mouse]Controlling malaria and African trypanosomiasis: The role of the mouse

Mice whose tumor necrosis factor alpha (TNF-) genes were disrupted developed higher levels of parasitemia than wild-type mice following infection with Trypanosoma congolense IL1180 or T. brucei brucei GUTat3.1, confirming the results of earlier studies. To determine whether TNF- directly affects ...


Kitani, H.Black, S.J.Nakamura, Y.Naessens, JanMurphy, N.Yokomizo, Y.Gibson, John P.Iraqi, F.A.[Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures]Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures

Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival...


Hernández Valladares, M.Naessens, JanMusoke, A.J.Sekikawa, K.Rihet, P.Ole-MoiYoi, O.K.Busher, P.Iraqi, F.A.[Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ]Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ
Iraqi, F.A.Kemp, Stephen J.Teale, A.J.[Fine mapping of trypanosomiasis resistance QTLs in mice using advanced intercross lines]Fine mapping of trypanosomiasis resistance QTLs in mice using advanced intercross lines
Koudande, O.D.Iraqi, F.A.Arendonk, Johan A.M. vanTeale, A.J.[Marker assisted introgression of multiple unlinked QTL: Experimental design and consequences]Marker assisted introgression of multiple unlinked QTL: Experimental design and consequences

The heat shock protein (HSP) 70.1 gene lies on mouse chromosome 17 among the candidates for Tir1, the major quantitative trait locus associated with response to Trypanosoma congolense infection. To evaluate whether the HSP70.1 gene is involved in the response, we compared the susceptibility of HS...


Nakamura, Y.Naessens, JanTakata, M.Taniguchi, T.Sekikawa, K.Gibson, John P.Iraqi, F.A.[Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection]Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection

Tumor necrosis factor-α (TNF-α) plays a role in the host’s defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can influence paras...


Kitani, H.Yagi, Y.Naessens, JanSekikawa, K.Iraqi, F.A.[The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-α gene]The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-α gene

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