A marker-assisted introgression (MAI) experiment was conducted to transfer trypanotolerance quantitative trait loci (QTL) from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. The objective was to assess the effect of three previously identified chromosomal regions on mouse chro...
Koudande, O.D.
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Thomson, P.C.
,
Bovenhuis, H.
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Iraqi, F.A.
,
Gibson, John P.
,
Arendonk, Johan A.M. van
,
[Biphasic survival analysis of trypanotolerance QTL in mice]
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Biphasic survival analysis of trypanotolerance QTL in mice
A number of linkage studies in human populations have identified a locus ( pfbi) on Chromosome 5q31-q33 controlling Plasmodiun falciparum blood infection levels. This region contains numerous candidate genes encoding immunological molecules such as cytokines, growth factors and growth-factor rec...
Hernández Valladares, M.
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Rihet, P.
,
Ole-MoiYoi, O.K.
,
Iraqi, F.A.
,
[Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human chromosome 5q31-q33]
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Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human chromosome 5q31-q33
This paper reports the results of a genome-wide search for quantitative trait loci (QTL) influencing immunological responses to infection with the gastro-intestinal nematode parasite Heligmosomoides polygyrus in an F2 population created by crossing the resistant SWR and the susceptible CBA inbr...
Menge, D.M.
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Behnke, J.M.
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Lowe, A.
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Gibson, John P.
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Iraqi, F.A.
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Baker, R.L.
,
Wakelin, D.
,
[Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice]
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Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice
Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...
Kemp, Stephen J.
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Iraqi, F.A.
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Darvasi, A.
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Soller, M.
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Teale, A.J.
,
[Localization of genes controlling resistance to trypanosomiasis in mice]
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Localization of genes controlling resistance to trypanosomiasis in mice
Quantitative trait loci (QTL) associated with resistance to an intestinal worm in a well-defined murine model are described. These have been identified in an F(2) population derived from resistant (SWR) and susceptible (CBA) parental mouse strains infected with the gastro-intestinal nematode par...
We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatel...
Hernández Valladares, M.
,
Naessens, Jan
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Gibson, John P.
,
Musoke, A.J.
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Nagda, S.M.
,
Rihet, P.
,
Ole-MoiYoi, O.K.
,
Iraqi, F.A.
,
[Confirmation and dissection of QTL controlling resistance to malaria in mice]
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Confirmation and dissection of QTL controlling resistance to malaria in mice