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Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-α (TNF-α), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia develop...


Naessens, JanKitani, H.Nakamura, Y.Yagi, Y.Sekikawa, K.Iraqi, F.A.[TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection]TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection

C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-α) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-α genes was correlated with the capacity to control parasitaemia and with survi...


Naessens, JanKitani, H.Momotani, E.Sekikawa, K.Nthale, J.M.Iraqi, F.A.[Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response]Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response

Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival...


Hernández Valladares, M.Naessens, JanMusoke, A.J.Sekikawa, K.Rihet, P.Ole-MoiYoi, O.K.Busher, P.Iraqi, F.A.[Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ]Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ
Iraqi, F.A.Kemp, Stephen J.Teale, A.J.[Fine mapping of trypanosomiasis resistance QTLs in mice using advanced intercross lines]Fine mapping of trypanosomiasis resistance QTLs in mice using advanced intercross lines

Fine mapping of quantitative trait loci (QTL) associated with resistance to the gastrointestinal parasite Heligmosomoides polygyrus was achieved on F6/F7 offspring (1076 mice) from resistant (SWR) and susceptible (CBA) mouse strains by selective genotyping (top and bottom 20% selected on total wo...


Behnke, J.M.Iraqi, F.A.Mugambi, J.M.M.Clifford, S.Nagda, S.M.Wakelin, D.Kemp, Stephen J.Leyden, B.Gibson, John P.[High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice]High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice

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