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Journal Article 2000

Autor: Behnke, J.M. Lowe, A. Menge, M. Iraqi, F.A. Wakelin, D.

GI nematodes are most commonly controlled by chemotherapy. Anthelmintic efficacy is decreasing as drug resistance becomes widespread and other approaches are needed. Knowledge of protective immunity against GI parasites is important for the development of vaccine strategies. Success in this field...

Enlace original: https://cgspace.cgiar.org/handle/10568/27968

Investigación en Agricultura
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Behnke, J.M. ,  Lowe, A. ,  Menge, M. ,  Iraqi, F.A. ,  Wakelin, D. ,  [Mapping genes for resistance to gastrointestinal nematodes] ,  Mapping genes for resistance to gastrointestinal nematodes
Journal Article 2006

Autor: Delhaye, N.F. Coltel, N. Puthier, D. Flori, L. Houlgatte, R. Iraqi, F.A. Nguyen, C. Grau, G.E. Rihet, P.

The development of cerebral malaria (CM) in mice with Plasmodium berghei ANKA infection is under genetic control. Brain gene-expression patterns were investigated in well-defined genetically CM-resistant (CM-R; BALB/c and DBA/2) and CM-susceptible (CM-S; C57BL/6 and CBA/J) mice by use of cDNA mic...

Enlace original: https://cgspace.cgiar.org/handle/10568/29649

Investigación en Agricultura
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Delhaye, N.F. ,  Coltel, N. ,  Puthier, D. ,  Flori, L. ,  Houlgatte, R. ,  Iraqi, F.A. ,  Nguyen, C. ,  Grau, G.E. ,  Rihet, P. ,  [Gene-expression profiling discriminates between cerebral malaria (CM) - susceptible mice and CM-resistant mice] ,  Gene-expression profiling discriminates between cerebral malaria (CM) - susceptible mice and CM-resistant mice
Journal Article 2004

Autor: Naessens, Jan Kitani, H. Momotani, E. Sekikawa, K. Nthale, J.M. Iraqi, F.A.

C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-alpha) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-alpha genes was correlated with the capacity to control parasitaemia and ...

Enlace original: https://cgspace.cgiar.org/handle/10568/29973

Investigación en Agricultura
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Naessens, Jan ,  Kitani, H. ,  Momotani, E. ,  Sekikawa, K. ,  Nthale, J.M. ,  Iraqi, F.A. ,  [Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response] ,  Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response
Journal Article 2008

Autor: Koudande, O.D. Thomson, P.C. Bovenhuis, H. Iraqi, F.A. Gibson, John P. Arendonk, Johan A.M. van

A marker-assisted introgression (MAI) experiment was conducted to transfer trypanotolerance quantitative trait loci (QTL) from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. The objective was to assess the effect of three previously identified chromosomal regions on mouse chro...

Enlace original: https://cgspace.cgiar.org/handle/10568/32934

Investigación en Agricultura
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Koudande, O.D. ,  Thomson, P.C. ,  Bovenhuis, H. ,  Iraqi, F.A. ,  Gibson, John P. ,  Arendonk, Johan A.M. van ,  [Biphasic survival analysis of trypanotolerance QTL in mice] ,  Biphasic survival analysis of trypanotolerance QTL in mice
Journal Article 1997

Autor: Kemp, Stephen J. Iraqi, F.A. Darvasi, A. Soller, M. Teale, A.J.

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...

Enlace original: https://cgspace.cgiar.org/handle/10568/1510

Investigación en Agricultura
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Kemp, Stephen J. ,  Iraqi, F.A. ,  Darvasi, A. ,  Soller, M. ,  Teale, A.J. ,  [Localisation of genes controlling resistance to trypanosomiasis in mice] ,  Localisation of genes controlling resistance to trypanosomiasis in mice
Journal Article 2010-06-22

Autor: Ng'ang'a, J.K. Soller, M. Iraqi, F.A.

Trypanosomosis is the most economically important disease constraint to livestock productivity in Africa. A number of trypanotolerant cattle breeds are found in West Africa, and identification of the genes conferring trypanotolerance could lead to effective means of genetic selection for trypanot...

Enlace original: https://cgspace.cgiar.org/handle/10568/2325

Investigación en Agricultura
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Ng'ang'a, J.K. ,  Soller, M. ,  Iraqi, F.A. ,  [High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele] ,  High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele
Journal Article 2007

Autor: Hernández Valladares, M. Naessens, Jan Iraqi, F.A.

Gene-knockout mice have been extensively used in the study of several malaria-induced pathologies. Some investigators believe that the deficient, infected mice mimic disease aspects produced in the absence of the target gene, but others believe that the deficient mice models mainly explain the ef...

Enlace original: https://cgspace.cgiar.org/handle/10568/33188

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Iraqi, F.A. ,  [Gene-knockout mice in malaria research: Useful or misleading?] ,  Gene-knockout mice in malaria research: Useful or misleading?
Journal Article 2005

Autor: Hernández Valladares, M. Naessens, Jan Iraqi, F.A.

Murine models have proved to be excellent tools in the support of studies of the human genetic bases of malaria resistance and have enabled the mapping of 12 resistance loci, eight of them controlling parasitic levels and four controlling cerebral malaria. Further studies using this method have i...

Enlace original: https://cgspace.cgiar.org/handle/10568/33187

Investigación en Agricultura
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Hernández Valladares, M. ,  Naessens, Jan ,  Iraqi, F.A. ,  [Genetic resistance to malaria in mouse models] ,  Genetic resistance to malaria in mouse models
Journal Article 2001

Autor: Iraqi, F.A. Sekikawa, K. Rowlands, G.J. Teale, A.J.

The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...

Enlace original: https://cgspace.cgiar.org/handle/10568/33087

Investigación en Agricultura
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Iraqi, F.A. ,  Sekikawa, K. ,  Rowlands, G.J. ,  Teale, A.J. ,  [Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection] ,  Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection
Journal Article 2010-02-15

Autor: Behnke, J.M. Menge, D.M. Nagda, S.M. Noyes, H. Iraqi, F.A. Kemp, Stephen J. Mugambi, R.J.M. Baker, R.L. Wakelin, D. Gibson, John P.

A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens...

Enlace original: https://cgspace.cgiar.org/handle/10568/358

Investigación en Agricultura
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Behnke, J.M. ,  Menge, D.M. ,  Nagda, S.M. ,  Noyes, H. ,  Iraqi, F.A. ,  Kemp, Stephen J. ,  Mugambi, R.J.M. ,  Baker, R.L. ,  Wakelin, D. ,  Gibson, John P. ,  [Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice] ,  Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

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