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Journal Article 2001

Autor: Wambugu, J. Kanguha, E. Hanotte, Olivier H. Davis, S. Taylor, J. Skow, L. Brunner, R. Schwerin, M. Teale, A.J. Iraqi, F.A.

Two bovine bacterial artificial chromosome clones were screened by PCR to amplify the tumour necrosis factor alpha (TNFA) gene. DNA extraction and Southern blotting and probing with a (GT)10 oligonucleotide were performed, followed by cloning into the pUC19 vector. A 0.9 kb fragment containing se...

Enlace original: https://cgspace.cgiar.org/handle/10568/28253

Investigación en Agricultura
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Wambugu, J. ,  Kanguha, E. ,  Hanotte, Olivier H. ,  Davis, S. ,  Taylor, J. ,  Skow, L. ,  Brunner, R. ,  Schwerin, M. ,  Teale, A.J. ,  Iraqi, F.A. ,  [Identification of two polymorphic microsatellite repeats on a bovine TNFA-containing BAC clone] ,  Identification of two polymorphic microsatellite repeats on a bovine TNFA-containing BAC clone
Journal Article 1997

Autor: Iraqi, F.A. Teale, A.J.

The C57BL/6 BALB/c and A/J inbred laboratory mouse strains often express different response phenotypes when challenged with a variety of infectious agents (Morrison et al. 1978; Bradley 1977; Hormmaeche et al. 1985). In view of the pivotal role of tumor necrosis factor Tnfa in innate immunity, we...

Enlace original: https://cgspace.cgiar.org/handle/10568/32941

Investigación en Agricultura
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Iraqi, F.A. ,  Teale, A.J. ,  [Cloning and sequencing of the Tnfa genes of three inbred mouse strains] ,  Cloning and sequencing of the Tnfa genes of three inbred mouse strains
Journal Article 1998

Autor: Iraqi, F.A. Teale, A.J.

The tumor necrosis factor (TNF) locus comprises the tandemly arranged genes coding for Tnfa (cachectin) and Tnfb (lymphotoxin-alpha) (Semon et al 1987). In mice, the TNF locus is located on chromosome 17 (MMU17) in the major histocompatibility complex (MHC) region. Tnfa and soluble lymphotoxin al...

Enlace original: https://cgspace.cgiar.org/handle/10568/32944

Investigación en Agricultura
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Iraqi, F.A. ,  Teale, A.J. ,  [Polymorphism in the microsatellite located in the promoters of the Tnfa and Tnfb genes of different mouse strains] ,  Polymorphism in the microsatellite located in the promoters of the Tnfa and Tnfb genes of different mouse strains
Journal Article 1999

Autor: Iraqi, F.A. Teale, A.J.

In view of the Tnfa gene location within the major histocompatibility (MHC) region and reports of its importance in disease protection activity, this paper examines the TNF a genes of a number of different mouse strains which were known to be of different disease response phenotypes. Twelve inbre...

Enlace original: https://cgspace.cgiar.org/handle/10568/32943

Investigación en Agricultura
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Iraqi, F.A. ,  Teale, A.J. ,  [Polymorphisms, in the Tnfa gene of different inbred mouse strains] ,  Polymorphisms, in the Tnfa gene of different inbred mouse strains
Journal Article 2008

Autor: Koudande, O.D. Thomson, P.C. Bovenhuis, H. Iraqi, F.A. Gibson, John P. Arendonk, Johan A.M. van

A marker-assisted introgression (MAI) experiment was conducted to transfer trypanotolerance quantitative trait loci (QTL) from a donor mouse strain, C57BL/6, into a recipient mouse strain, A/J. The objective was to assess the effect of three previously identified chromosomal regions on mouse chro...

Enlace original: https://cgspace.cgiar.org/handle/10568/32934

Investigación en Agricultura
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Koudande, O.D. ,  Thomson, P.C. ,  Bovenhuis, H. ,  Iraqi, F.A. ,  Gibson, John P. ,  Arendonk, Johan A.M. van ,  [Biphasic survival analysis of trypanotolerance QTL in mice] ,  Biphasic survival analysis of trypanotolerance QTL in mice
Journal Article 2003

Autor: Behnke, J.M. Iraqi, F.A. Menge, D. Baker, R.L. Gibson, John P. Wakelin, D.

The host-protective immune response to infection with gastrointestinal (GI) nematodes involves a range of interacting processes that begin with recognition of the parasite's antigens and culminate in an inflammatory reaction in the intestinal mucosa. Precisely which immune effectors are responsib...

Enlace original: https://cgspace.cgiar.org/handle/10568/33007

Investigación en Agricultura
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Behnke, J.M. ,  Iraqi, F.A. ,  Menge, D. ,  Baker, R.L. ,  Gibson, John P. ,  Wakelin, D. ,  [Chasing the genes that control resistance to gastrointestinal nematodes] ,  Chasing the genes that control resistance to gastrointestinal nematodes
Journal Article 2006

Autor: Behnke, J.M. Mugambi, J.M.M. Clifford, S. Iraqi, F.A. Baker, R.L. Gibson, John P. Wakelin, D.

Since the publication of the mouse genome, attention has focused on the strains that were selected for sequencing. In this paper we report the results of experiments that characterized the response to infection with the murine gastrointestinal nematode Heligmosomoides polygyrus of eight new strai...

Enlace original: https://cgspace.cgiar.org/handle/10568/33090

Investigación en Agricultura
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Behnke, J.M. ,  Mugambi, J.M.M. ,  Clifford, S. ,  Iraqi, F.A. ,  Baker, R.L. ,  Gibson, John P. ,  Wakelin, D. ,  [Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project] ,  Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project
Journal Article 1997

Autor: Kemp, Stephen J. Iraqi, F.A. Darvasi, A. Soller, M. Teale, A.J.

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...

Enlace original: https://cgspace.cgiar.org/handle/10568/33074

Investigación en Agricultura
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Kemp, Stephen J. ,  Iraqi, F.A. ,  Darvasi, A. ,  Soller, M. ,  Teale, A.J. ,  [Localization of genes controlling resistance to trypanosomiasis in mice] ,  Localization of genes controlling resistance to trypanosomiasis in mice
Journal Article 2003

Autor: Wang, M. Lemon, W.J. Liu, G. Wang, Y. Iraqi, F.A. Malkinson, A.M. You, M.

In the present study, we used newly developed F11 generation mouse advanced intercross lines (AIL) to fine map Pas1–3 quantitative trait loci (QTL). The (A/J x C57BL/6) F11 AIL mouse population was created by crossing lung tumor-resistant C57BL/6 mice with lung tumor-susceptible A/J mice. By se...

Enlace original: https://cgspace.cgiar.org/handle/10568/32868

Investigación en Agricultura
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Wang, M. ,  Lemon, W.J. ,  Liu, G. ,  Wang, Y. ,  Iraqi, F.A. ,  Malkinson, A.M. ,  You, M. ,  [Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines] ,  Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines
Journal Article 2005

Autor: Flori, L. Delahaye, N.F. Iraqi, F.A. Hernández Valladares, M. Fumoux, F. Rihet, P.

We have previously obtained strong evidence for linkage of mild malaria attack to the MHC region, with a peak close to the tumor necrosis factor (TNF) gene. We screened, for polymorphisms, the entire TNF gene in the same sample of 34 families comprising 197 individuals living in a Plasmodium falc...

Enlace original: https://cgspace.cgiar.org/handle/10568/28659

Investigación en Agricultura
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Flori, L. ,  Delahaye, N.F. ,  Iraqi, F.A. ,  Hernández Valladares, M. ,  Fumoux, F. ,  Rihet, P. ,  [TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso] ,  TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso

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