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Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-alpha (TNF-alpha), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia...


Naessens, JanKitani, H.Nakamura, Y.Yagi, Y.Sekikawa, K.Iraqi, F.A.[TNF-alpha mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection]TNF-alpha mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection

C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-alpha) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-alpha genes was correlated with the capacity to control parasitaemia and ...


Naessens, JanKitani, H.Momotani, E.Sekikawa, K.Nthale, J.M.Iraqi, F.A.[Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response]Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response

Mice whose tumor necrosis factor alpha (TNF-) genes were disrupted developed higher levels of parasitemia than wild-type mice following infection with Trypanosoma congolense IL1180 or T. brucei brucei GUTat3.1, confirming the results of earlier studies. To determine whether TNF- directly affects ...


Kitani, H.Black, S.J.Nakamura, Y.Naessens, JanMurphy, N.Yokomizo, Y.Gibson, John P.Iraqi, F.A.[Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures]Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in Axenic cultures

We have previously reported the results of genome-wide searches in two murine F2 populations for QTLs that influence survival following Trypanosoma congolense infection. Three loci, Tir1, Tir2, and Tir3, were identified and mapped to mouse Chromosomes (Chrs) 17, 5, and 1 respectively, with confid...


Iraqi, F.A.Clapcott, S.J.Kumari, P.Haley, C.S.Kemp, Stephen J.Teale, A.J.[Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines]Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines

Trypanosoma congolense is a protozoan parasite that causes severe diseases in livestock. Three major quantative trait loci (QTL), Tir1, Tir2, and Tir3, control the survival time of mice after infection with T. congolense. Congenic mice carrying the C57BL/6 resistance alleles on the A/J background...


Rathkolb, B.Noyes, H.A.Brass, A.Dark, P.Fuchs, H.Gailus-Durner, V.Gibson, John P.Angelis, M.H. deOgugo, M.Iraqi, F.A.Kemp, Stephen J.Naessens, JanPope, M.E.Wolf, E.Agaba, Morris[Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection]Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection

Trypanosoma congolense are extracellular protozoan parasites of the blood stream of artiodactyls and are one of the main constraints on cattle production in Africa. In cattle, anaemia is the key feature of disease and persists after parasitaemia has declined to low or undetectable levels, but tre...


Noyes, H.A.Alimohammadian, M.H.Agaba, MorrisBrass, A.Fuchs, H.Gailus-Durner, V.Hulme, H.Iraqi, F.A.Kemp, Stephen J.Rathkolb, B.Wolf, E.Angelis, M.H. deRoshandel, D.Naessens, Jan[Mechanisms controlling anaemia in Trypanosoma congolense infected mice]Mechanisms controlling anaemia in Trypanosoma congolense infected mice

The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...


Iraqi, F.A.Sekikawa, K.Rowlands, G.J.Teale, A.J.[Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection]Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection

Tumor necrosis factor-[alpha] (TNF-[alpha]) plays a role in the host's defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can inf...


Kitani, H.Yagi, Y.Naessens, JanSekikawa, K.Iraqi, F.A.[The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene]The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene

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