This paper undertakes an ex ante economic analysis of research on how resistance to trypanosomosis - a dominant livestock disease in Africa - can be maintained and enhanced while retaining and reinforcing characteristics of economic importance to farmers, and on how 'trypanotolerance' can be impa...
Falconi, C.A.
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Omamo, S.W.
,
D'Ieteren, G.D.M.
,
Iraqi, F.A.
,
[An ex ante economic and policy analysis of research on genetic resistance to livestock disease: Trypanosomiasis in Africa]
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An ex ante economic and policy analysis of research on genetic resistance to livestock disease: Trypanosomiasis in Africa
GI nematodes are most commonly controlled by chemotherapy. Anthelmintic efficacy is decreasing as drug resistance becomes widespread and other approaches are needed. Knowledge of protective immunity against GI parasites is important for the development of vaccine strategies. Success in this field...
Behnke, J.M.
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Lowe, A.
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Menge, M.
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Iraqi, F.A.
,
Wakelin, D.
,
[Mapping genes for resistance to gastrointestinal nematodes]
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Mapping genes for resistance to gastrointestinal nematodes
The development of cerebral malaria (CM) in mice with Plasmodium berghei ANKA infection is under genetic control. Brain gene-expression patterns were investigated in well-defined genetically CM-resistant (CM-R; BALB/c and DBA/2) and CM-susceptible (CM-S; C57BL/6 and CBA/J) mice by use of cDNA mic...
Ng'ang'a, J.
,
Iraqi, F.A.
,
[Expression variation of TLR as candidate genes underlying trypanotolerance QTL in mice]
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Expression variation of TLR as candidate genes underlying trypanotolerance QTL in mice
Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-α (TNF-α), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia develop...
Naessens, Jan
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Kitani, H.
,
Nakamura, Y.
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Yagi, Y.
,
Sekikawa, K.
,
Iraqi, F.A.
,
[TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection]
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TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection
Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-alpha (TNF-alpha), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia...
Naessens, Jan
,
Kitani, H.
,
Nakamura, Y.
,
Yagi, Y.
,
Sekikawa, K.
,
Iraqi, F.A.
,
[TNF-alpha mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection]
,
TNF-alpha mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection
C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-α) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-α genes was correlated with the capacity to control parasitaemia and with survi...
Naessens, Jan
,
Kitani, H.
,
Momotani, E.
,
Sekikawa, K.
,
Nthale, J.M.
,
Iraqi, F.A.
,
[Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response]
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Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response
C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-alpha) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-alpha genes was correlated with the capacity to control parasitaemia and ...
Naessens, Jan
,
Kitani, H.
,
Momotani, E.
,
Sekikawa, K.
,
Nthale, J.M.
,
Iraqi, F.A.
,
[Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response]
,
Susceptibility of TNF-alpha-deficient mice to Trypanosoma congolense is not due to a defective antibody response
Two bovine bacterial artificial chromosome clones were screened by PCR to amplify the tumour necrosis factor alpha (TNFA) gene. DNA extraction and Southern blotting and probing with a (GT)10 oligonucleotide were performed, followed by cloning into the pUC19 vector. A 0.9 kb fragment containing se...
Wambugu, J.
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Kanguha, E.
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Hanotte, Olivier H.
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Davis, S.
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Taylor, J.
,
Skow, L.
,
Brunner, R.
,
Schwerin, M.
,
Teale, A.J.
,
Iraqi, F.A.
,
[Identification of two polymorphic microsatellite repeats on a bovine TNFA-containing BAC clone]
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Identification of two polymorphic microsatellite repeats on a bovine TNFA-containing BAC clone
The C57BL/6 BALB/c and A/J inbred laboratory mouse strains often express different response phenotypes when challenged with a variety of infectious agents (Morrison et al. 1978; Bradley 1977; Hormmaeche et al. 1985). In view of the pivotal role of tumor necrosis factor Tnfa in innate immunity, we...
Iraqi, F.A.
,
Teale, A.J.
,
[Cloning and sequencing of the Tnfa genes of three inbred mouse strains]
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Cloning and sequencing of the Tnfa genes of three inbred mouse strains