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As a first step in developing compartment-specific markers for protein trafficking within Theileria parva, we have isolated cDNAs encoding homologues of the small GTP binding proteins Rab1 and Rab4. The T. parva homologue of Rab1 (TpRab1), a protein which regulates vesicular transport between the...


Janoo, R.T.K.Musoke, A.J.Wells, C.Bishop, Richard P.[A Rab1 homologue with a novel isoprenylation signal provides insight into the secretory pathway of Theileria parva]A Rab1 homologue with a novel isoprenylation signal provides insight into the secretory pathway of Theileria parva

Recent studies suggest that peptidyl-prolyl isomerases of the cyclophilin family, that access the secretory pathway, can be involved in the interaction of parasitic protozoa with mammalian host cells. The amino acid sequence of a cDNA encoding a cyclophilin family member of the intracellular pro...


Ebel, T.Pelle, RogerJanoo, R.T.K.Lipp, J.Bishop, Richard P.[A membrane-anchored Theileria parva cyclophilin with a non-cleaved amino-terminal signal peptide for entry into the endoplasmic reticulum]A membrane-anchored Theileria parva cyclophilin with a non-cleaved amino-terminal signal peptide for entry into the endoplasmic reticulum

Molecules located on cell surfaces and those that are secreted from the cell frequently play a critical role in cell biology by mediating interaction with the external environment. These types of parasite molecules often constitute targets for protective host immune responses and are thus of addi...


Musembi, S.Janoo, R.T.K.Sohanpal, B.K.Ochanda, H.Ole-MoiYoi, O.K.Bishop, Richard P.Nene, Vishvanath[Screening for Theileria parva secretory gene products by functional analysis in Saccharomyces cerevisiae]Screening for Theileria parva secretory gene products by functional analysis in Saccharomyces cerevisiae

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