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Heterogeneity between centers in multicenter trials with time to event outcome can be modeled by the frailty proportional hazards model. The majority of the different approaches that have been used to fit frailty models assume either the gamma or the lognormal frailty density and are based on sim...


Duchateau, L.Janssen, P.Lindsey, P.Legrand, C.Nguti, R.Sylvester-Bradley, Rosemary[The shared frailty model and the power for heterogeneity tests in multicenter trials]The shared frailty model and the power for heterogeneity tests in multicenter trials

We considered the analysis of a study for Dorper, Red Maasai and crossbred lambs born over a period of 6 years at the Diani Estate, Kenya. The study was designed to compare survival and performance traits of genotypes with differing susceptibilities to helminthiasis. The available data include in...


Nguti, R.Burzykowski, T.Rowlands, G.J.Renard, D.Janssen, P.[Joint modelling of repeated measurements and event time: Application to performance traits and survival of lambs bred in sub-humid tropics]Joint modelling of repeated measurements and event time: Application to performance traits and survival of lambs bred in sub-humid tropics

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