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Heartwater, a tick-borne disease of domestic and wild ruminants, is caused by the intracellular rickettsia Ehrlichia ruminantium (previously known as Cowdria ruminantium). It is a major constraint to livestock production throughout subSaharan Africa, and it threatens to invade the Americas, yet t...


Collins, N.E.Liebenberg, J.Villiers, Etienne P. deBrayton, K.A.Louw, E.Pretorius, A.Faber, F.E.Heerden, H. vanJosemans, A.Kleef, M. vanSteyn, H.C.Strijp, M.F. vanZweygarth, E.Jongejan, F.Maillard, J.C.Berthier, D.Botha, M.Joubert, F.Corton, C.H.Thomson, N.R.Allsopp, M.T.Allsopp, B.A.[The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number]The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number

The response of peripheral blood mononuclear cells (PBMC) collected from cattle immunized with killed C. ruminantium to MAP1, MAP1-B, MAP2 and to a lysate of Cowdria was characterized in vitro. CD4+ T lymphocytes responded strongly to Cowdria lysates while B cells and gamma delta T cells prolifer...


Totte, P.McKeever, Declan J.Jongejan, F.Barbet, A.Mahan, S.M.Mwangi, D.Bensaid, A.[Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium]Analysis of cellular responses to native and recombinant proteins of Cowdria ruminantium

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