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Aye, RachealWeldearegay, Yenehiwot BerhanuLutta, H.O.Chuma, FrancisPich, A.Jores, JoergMeens, J.Naessens, Jan[Identification of targets of monoclonal antibodies that inhibit adhesion and growth in Mycoplasma mycoides subspecies mycoides]Identification of targets of monoclonal antibodies that inhibit adhesion and growth in Mycoplasma mycoides subspecies mycoides

Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully attenuated via targeted deletion of non-essent...


Jores, JoergMa, L.Ssajjakambwe, PaulSchieck, Elise G.Liljander, Anne M.Chandran, S.Stoffel, M.H.Cippa, V.Arfi, Y.Assad-Garcia, N.Falquet, L.Sirand-Pugnet, P.Blanchard, AlainLartigue, C.Posthaus, H.Labroussaa, F.Vashee, S.[Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain]Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain

Mycoplasma species are responsible for several economically significant livestock diseases for which there is a need for new and improved vaccines. Most of the existing mycoplasma vaccines are attenuated strains that have been empirically obtained by serial passages or by chemical mutagenesis. Th...


Lartigue, C.Valverde Timana, Y.Labroussaa, F.Schieck, Elise G.Liljander, Anne M.Sacchini, FlavioPosthaus, H.Batailler, B.Sirand-Pugnet, P.Vashee, S.Jores, JoergBlanchard, Alain[Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches]Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches

Five Mycoplasma strains from wild Caprinae were analyzed: four from Alpine ibex (Capra ibex) which died at the Berlin Zoo between 1993 and 1994, one from a Rocky Mountain goat collected in the USA prior to 1987. These five strains represented a population different from the populations belonging ...


Jores, JoergFischer, A.Sirand-Pugnet, P.Thomann, A.Liebler-Tenorio, E.M.Schnee, C.Santana-Cruz, I.Heller, M.Frey, J.[Mycoplasma feriruminatoris sp. nov., a fast growing Mycoplasma species isolated from wild Caprinae]Mycoplasma feriruminatoris sp. nov., a fast growing Mycoplasma species isolated from wild Caprinae

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