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Introduction: The bacterium Mycoplasma capricolum subsp. capricolum is known as a pathogen in goats. There have been no reports on a zoonotic potential so far. Case presentation: A case of septicaemia and meningoencephalitis in a 62-year-old patient has been associated with infection by M. capric...


Heller, M.Schwarz, R.Noe, G.Jores, JoergFischer, A.Schubert, E.Sachse, K.[First human case of severe septicaemia associated with Mycoplasma capricolum subsp. Capricolum infection]First human case of severe septicaemia associated with Mycoplasma capricolum subsp. Capricolum infection

Contagious bovine pleuropneumonia (CBPP) caused by Mycoplasma mycoides subsp. mycoides (Mmm) is an economically very important cattle disease in sub-Saharan Africa. CBPP impacts animal health and poverty of livestock-dependent people through decreased animal productivity, reduced food supply, and...


Jores, JoergMariner, Jeffrey C.Naessens, Jan[Development of an improved vaccine for contagious bovine pleuropneumonia: An African perspective on challenges and proposed actions]Development of an improved vaccine for contagious bovine pleuropneumonia: An African perspective on challenges and proposed actions

Contagious caprine pleuropneumonia (CCPP) caused by Mycoplasma capricolum subsp. capripneumoniae is a severe epidemic affecting mainly domestic Caprinae species but also affects wild Caprinae species. M. capricolum subsp. capripneumoniae belongs to the “Mycoplasma mycoides cluster.” The disease f...


Falquet, LaurentLiljander, Anne M.Schieck, Elise G.Gluecks, Ilona V.Frey, J.Jores, Joerg[Complete genome sequences of virulent Mycoplasma capricolum subsp. capripneumoniae strains F38 and ILRI181]Complete genome sequences of virulent Mycoplasma capricolum subsp. capripneumoniae strains F38 and ILRI181

Mycoplasma mycoides subsp. capri (Mmc) and subsp. mycoides (Mmm) are important ruminant pathogens worldwide causing diseases such as pleuropneumonia, mastitis and septicaemia. They express galactofuranose residues on their surface, but their role in pathogenesis has not yet been determined. The M...


Schieck, Elise G.Lartigue, C.Frey, J.Vozza, N.Hegermann, J.Miller, R.A.Valguarnera, E.Muriuki, C.Meens, J.Nene, VishvanathNaessens, JanWeber, J.Lowary, T.L.Vashee, S.Feldman, M.F.Jores, Joerg[Galactofuranose in Mycoplasma mycoides is important for membrane integrity and conceals adhesins but does not contribute to serum resistance]Galactofuranose in Mycoplasma mycoides is important for membrane integrity and conceals adhesins but does not contribute to serum resistance

Contagious caprine pleuropneumonia (CCPP) is a highly contagious disease caused by Mycoplasma capricolum subsp. capripneumoniae that affects goats in Africa and Asia. Current available methods for the diagnosis of Mycoplasma infection, including cultivation, serological assays, and PCR, are time-...


Liljander, Anne M.Mingyan YuO'Brien, E.Heller, M.Nepper, J.F.Weibel, D.B.Gluecks, Ilona V.Younan, M.Frey, J.Falquet, LaurentJores, Joerg[Field-applicable recombinase polymerase amplification assay for rapid detection of Mycoplasma capricolum subsp. Capripneumonia]Field-applicable recombinase polymerase amplification assay for rapid detection of Mycoplasma capricolum subsp. Capripneumonia

Derda, R.Gitaka, J.Klapperich, C.M.Mace, C.R.Kumar, A.A.Lieberman, M.Linnes, J.C.Jores, JoergNasimolo, J.Ndung'u, J.M.Taracha, E.A.Weaver, A.Weibel, D.B.Kariuki, T.M.Yager, P.[Enabling the development and deployment of next generation point-of-care diagnostics]Enabling the development and deployment of next generation point-of-care diagnostics

Members of the Mycoplasma mycoides cluster’ represent important livestock pathogens worldwide. Mycoplasma mycoidessubsp. mycoides is the etiologic agent of contagious bovine pleuropneumonia (CBPP), which is still endemic in many parts of Africa. We report the genome sequences and annotation of tw...


Fischer, A.Santana-Cruz, I.Hegerman, J.Gourle, H.Schieck, Elise G.Lambert, M.Nadendla, S.Wesonga, H.O.Miller, R.A.Vashee, S.Weber, J.Meens, J.Frey, J.Jores, Joerg[High quality draft genomes of the Mycoplasma mycoides subsp.mycoides challenge strains Afadé and B237]High quality draft genomes of the Mycoplasma mycoides subsp.mycoides challenge strains Afadé and B237

Shiga toxin-producing Escherichia coli (STEC) cause gastrointestinal illnesses including non-bloody or bloody diarrhoea, haemorrhagic colitis (HC), and the haemolytic uremic syndrome (HUS). To investigate the occurrence of STEC among grazing dromedaries from Kenya, E. coli isolated from fecal mat...


Baschera, M.Cernela, N.Stevens, M.J.A.Liljander, Anne M.Jores, JoergMax Corman, V.Nüesch-Inderbinen, M.Stephan, R.[Shiga toxin-producing Escherichia coli (STEC) isolated from fecal samples of African dromedary camels]Shiga toxin-producing Escherichia coli (STEC) isolated from fecal samples of African dromedary camels

Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully attenuated via targeted deletion of non-essent...


Jores, JoergMa, L.Ssajjakambwe, PaulSchieck, Elise G.Liljander, Anne M.Chandran, S.Stoffel, M.H.Cippa, V.Arfi, Y.Assad-Garcia, N.Falquet, L.Sirand-Pugnet, P.Blanchard, AlainLartigue, C.Posthaus, H.Labroussaa, F.Vashee, S.[Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain]Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain

Mycoplasma species are responsible for several economically significant livestock diseases for which there is a need for new and improved vaccines. Most of the existing mycoplasma vaccines are attenuated strains that have been empirically obtained by serial passages or by chemical mutagenesis. Th...


Lartigue, C.Valverde Timana, Y.Labroussaa, F.Schieck, Elise G.Liljander, Anne M.Sacchini, FlavioPosthaus, H.Batailler, B.Sirand-Pugnet, P.Vashee, S.Jores, JoergBlanchard, Alain[Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches]Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches

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