Mycoplasma capricolum subsp. capricolum is a well-known pathogen of small ruminants. A recent human case of septicemia involving this agent raised the question of its potential pathogenicity to humans. We present the first draft genome sequence of a human Mycoplasma capricolum subsp. capricolum i...
Seersholm, F.V.
,
Fischer, A.
,
Heller, M.
,
Jores, Joerg
,
Sachse, K.
,
Mourier, T.
,
Hansen, A.J.
,
[Draft genome sequence of the first human isolate of the ruminant pathogen Mycoplasma capricolum subsp. capricolum]
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Draft genome sequence of the first human isolate of the ruminant pathogen Mycoplasma capricolum subsp. capricolum
Contagious bovine pleuropneumonia (CBPP) caused by Mycoplasma mycoides subsp.
mycoides (Mmm) is an economically very important cattle disease in sub-Saharan Africa.
CBPP impacts animal health and poverty of livestock-dependent people through decreased
animal productivity, reduced food supply, and...
Jores, Joerg
,
Mariner, Jeffrey C.
,
Naessens, Jan
,
[Development of an improved vaccine for contagious bovine pleuropneumonia: An African perspective on challenges and proposed actions]
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Development of an improved vaccine for contagious bovine pleuropneumonia: An African perspective on challenges and proposed actions
Mycoplasma mycoides subsp. capri (Mmc) and subsp. mycoides (Mmm) are important ruminant pathogens worldwide causing diseases such as pleuropneumonia, mastitis and septicaemia. They express galactofuranose residues on their surface, but their role in pathogenesis has not yet been determined. The M...
Schieck, Elise G.
,
Lartigue, C.
,
Frey, J.
,
Vozza, N.
,
Hegermann, J.
,
Miller, R.A.
,
Valguarnera, E.
,
Muriuki, C.
,
Meens, J.
,
Nene, Vishvanath
,
Naessens, Jan
,
Weber, J.
,
Lowary, T.L.
,
Vashee, S.
,
Feldman, M.F.
,
Jores, Joerg
,
[Galactofuranose in Mycoplasma mycoides is important for membrane integrity and conceals adhesins but does not contribute to serum resistance]
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Galactofuranose in Mycoplasma mycoides is important for membrane integrity and conceals adhesins but does not contribute to serum resistance
Contagious caprine pleuropneumonia (CCPP) is a highly contagious disease caused by Mycoplasma capricolum subsp. capripneumoniae that affects goats in Africa and Asia. Current available methods for the diagnosis of Mycoplasma infection, including cultivation, serological assays, and PCR, are time-...
Derda, R.
,
Gitaka, J.
,
Klapperich, C.M.
,
Mace, C.R.
,
Kumar, A.A.
,
Lieberman, M.
,
Linnes, J.C.
,
Jores, Joerg
,
Nasimolo, J.
,
Ndung'u, J.M.
,
Taracha, E.A.
,
Weaver, A.
,
Weibel, D.B.
,
Kariuki, T.M.
,
Yager, P.
,
[Enabling the development and deployment of next generation point-of-care diagnostics]
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Enabling the development and deployment of next generation point-of-care diagnostics
Shiga toxin-producing Escherichia coli (STEC) cause gastrointestinal illnesses including non-bloody or bloody diarrhoea, haemorrhagic colitis (HC), and the haemolytic uremic syndrome (HUS). To investigate the occurrence of STEC among grazing dromedaries from Kenya, E. coli isolated from fecal mat...
Baschera, M.
,
Cernela, N.
,
Stevens, M.J.A.
,
Liljander, Anne M.
,
Jores, Joerg
,
Max Corman, V.
,
Nüesch-Inderbinen, M.
,
Stephan, R.
,
[Shiga toxin-producing Escherichia coli (STEC) isolated from fecal samples of African dromedary camels]
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Shiga toxin-producing Escherichia coli (STEC) isolated from fecal samples of African dromedary camels
Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully attenuated via targeted deletion of non-essent...
Jores, Joerg
,
Ma, L.
,
Ssajjakambwe, Paul
,
Schieck, Elise G.
,
Liljander, Anne M.
,
Chandran, S.
,
Stoffel, M.H.
,
Cippa, V.
,
Arfi, Y.
,
Assad-Garcia, N.
,
Falquet, L.
,
Sirand-Pugnet, P.
,
Blanchard, Alain
,
Lartigue, C.
,
Posthaus, H.
,
Labroussaa, F.
,
Vashee, S.
,
[Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain]
,
Removal of a subset of non-essential genes fully attenuates a highly virulent Mycoplasma strain
Mycoplasma species are responsible for several economically significant livestock diseases for which there is a need for new and improved vaccines. Most of the existing mycoplasma vaccines are attenuated strains that have been empirically obtained by serial passages or by chemical mutagenesis. Th...
Lartigue, C.
,
Valverde Timana, Y.
,
Labroussaa, F.
,
Schieck, Elise G.
,
Liljander, Anne M.
,
Sacchini, Flavio
,
Posthaus, H.
,
Batailler, B.
,
Sirand-Pugnet, P.
,
Vashee, S.
,
Jores, Joerg
,
Blanchard, Alain
,
[Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches]
,
Attenuation of a pathogenic Mycoplasma strain by modification of the obg gene by using synthetic biology approaches
To analyze the distribution of Middle East respiratory syndrome coronavirus (MERS-CoV)–seropositive dromedary camels in eastern Africa, we tested 189 archived serum samples accumulated during the past 30 years. We identified MERS-CoV neutralizing antibodies in 81.0% of samples from the main camel...
Muller, M.A.
,
Corman, V.M.
,
Jores, Joerg
,
Meyer, B.
,
Younan, M.
,
Liljander, Anne M.
,
Bosch, B.J.
,
Lattwein, E.
,
Hilali, M.
,
Musa, B.E.
,
Bornstein, S.
,
Drosten, C.
,
[MERS coronavirus neutralizing antibodies in camels, eastern Africa, 1983-1997]
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MERS coronavirus neutralizing antibodies in camels, eastern Africa, 1983-1997