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Trypanosoma congolense are extracellular protozoan parasites of the blood stream of artiodactyls and are one of the main constraints on cattle production in Africa. In cattle, anaemia is the key feature of disease and persists after parasitaemia has declined to low or undetectable levels, but tre...


Noyes, H.A.Alimohammadian, M.H.Agaba, MorrisBrass, A.Fuchs, H.Gailus-Durner, V.Hulme, H.Iraqi, F.A.Kemp, Stephen J.Rathkolb, B.Wolf, E.Angelis, M.H. deRoshandel, D.Naessens, Jan[Mechanisms controlling anaemia in Trypanosoma congolense infected mice]Mechanisms controlling anaemia in Trypanosoma congolense infected mice

Conventional disciplinary research approach is losing momentum in the face of dynamic health challenges of the 21st century. There is a need for a new, suitable approach, to tackle these emerging and re-emerging human and animal diseases through integrating livestock and human health research in ...


Tibbo, MarkosSchelling, E.Grace, DeliaBishop, Richard P.Taracha, E.A.Kemp, Stephen J.Ameni, G.Dawo, F.Randolph, Thomas F.[Cross-disciplinary and participatory livestock and human health research for successful control of zoonoses in the developing world]Cross-disciplinary and participatory livestock and human health research for successful control of zoonoses in the developing world

Background: Familial pancreatic cancer (FPC) describes a group of families where the inheritance of pancreatic cancer is consistent with an autosomal-dominant mode of inheritance. The 4q32-34 region has been previously identified as a potential locus for FPC in a large American family.


Earl, J.Yan, L.Vitone, L.J.Risk, J.Kemp, Stephen J.McFaul, C.Neoptolemos, J.P.Greenhalf, W.Kress, R.Sina-Frey, M.Hahn, S.Rieder, H.Bartsch, D.K.[Evaluation of the 4q32-34 Locus in European familial pancreatic cancer]Evaluation of the 4q32-34 Locus in European familial pancreatic cancer
Kemp, Stephen J.Spooner, R.L.Teale, A.J.[A comparative study of major histocompatibility complex antigens in East African and European cattle breeds]A comparative study of major histocompatibility complex antigens in East African and European cattle breeds

A panel of 81 new polymorphic bovine microsatellite markers is described, together with further information on a previously reported group of 16 markers. The mean polymorphism information content of the 97 markers determined in 20 cattle was 0.66. Seventy-three of these markers have been assigned...


Kemp, Stephen J.Hishida, OWambugu, J.Rink, A.Longeri, M.L.Ma, R.Z.Da, Y.Lewin, H.A.Barendse, W.Teale, A.J.[A panel of polymorphic bovine, ovine and caprine microsatellite markers]A panel of polymorphic bovine, ovine and caprine microsatellite markers

A small number of west African Bos taurus cattle breeds, including the N'Dama, constitute a valuable genetic resource by virtue of their ability to remain productive under trypanosomiasis challenge. However, introgression of Bos indicus genes into the trypanotolerant breeds, particularly by intro...


Teale, A.J.Wambugu, J.Gwakisa, P.S.Stranzinger, G.Bradley, D.Kemp, Stephen J.[A polymorphism in randomly amplified DNA which differentiates the Y chromosomes of Bos indicus and Bos taurus]A polymorphism in randomly amplified DNA which differentiates the Y chromosomes of Bos indicus and Bos taurus
Iraqi, F.A.Kemp, Stephen J.Teale, A.J.[Fine mapping of trypanosomiasis resistance QTLs in mice using advanced intercross lines]Fine mapping of trypanosomiasis resistance QTLs in mice using advanced intercross lines

Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the severe anaemia and production loss...


Kemp, Stephen J.Teale, A.J.[The genetic basis of trypanotolerance in mice and cattle]The genetic basis of trypanotolerance in mice and cattle

We describe 10 polymorphic tetranucleotide microsatellite loci from the eastern Canary Island lacertid lizard, Gallotia atlantica. Loci were isolated from a partial genomic library that had been enriched for AAAG repeat sequence. All loci were highly polymorphic (eight alleles or more) with obser...


Bloor, P.Laguna, I.H.B.Kemp, Stephen J.[Highly polymorphic tetranucleotide microsatellite loci for the eastern Canary Island lizard, Gallotia atlantica]Highly polymorphic tetranucleotide microsatellite loci for the eastern Canary Island lizard, Gallotia atlantica

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...


Kemp, Stephen J.Iraqi, F.A.Darvasi, A.Soller, M.Teale, A.J.[Localisation of genes controlling resistance to trypanosomiasis in mice]Localisation of genes controlling resistance to trypanosomiasis in mice

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