African animal trypanosomiasis (AAT) caused by tsetse fly-transmitted protozoa of the genus Trypanosoma is a major constraint on livestock and agricultural production in Africa and is among the top ten global cattle diseases impacting on the poor. Here we show that a functional genomics approach ...
O'Gorman, G.M.
,
Park, S. de
,
Hill, E.W.
,
Meade, K.G.
,
Coussens, P.M.
,
Agaba, Morris
,
Naessens, Jan
,
Kemp, Stephen J.
,
MacHugh, D.E.
,
[Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility]
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Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility
Silva Pereira, S.
,
Casas-Sánchez, A.
,
Haines, L.R.
,
Ogugo, Moses W.
,
Kihara, Absolomon
,
Sanders, M.
,
Kemp, Stephen J.
,
Acosta-Serrano, Á.
,
Noyes, H.
,
Berriman, M.
,
Jackson, A.P.
,
[Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs]
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Variant antigen repertoires in Trypanosoma congolense populations and experimental infections can be profiled from deep sequence data using universal protein motifs
West African N'Dama cattle have developed a genetic capacity to survive, reproduce and remain productive under trypanosomosis risk. The cellular and molecular bases of this so-called trypanotolerance are not known, but the trait is manifested by the N'Dama's greater capacity to control parasitae...
Naessens, Jan
,
Leak, S.G.A.
,
Kennedy, D.J.
,
Kemp, Stephen J.
,
Teale, A.J.
,
[Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense]
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Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense
West African N'Dama cattle have developed a genetic capacity to survive, reproduce and remain productive under trypanosomosis risk. The cellular and molecular bases of this so-called trypanotolerance are not known, but the trait is manifested by the N'Dama's greater capacity to control parasitaem...
Naessens, Jan
,
Leak, S.G.A.
,
Kennedy, D.J.
,
Kemp, Stephen J.
,
Teale, A.J.
,
[Responses of bovine chimaeras combining trypanosomiasis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense]
,
Responses of bovine chimaeras combining trypanosomiasis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense
We have previously reported the results of genome-wide searches in two murine F2 populations for QTLs that influence survival following Trypanosoma congolense infection. Three loci, Tir1, Tir2, and Tir3, were identified and mapped to mouse Chromosomes (Chrs) 17, 5, and 1 respectively, with confid...
Iraqi, F.A.
,
Clapcott, S.J.
,
Kumari, P.
,
Haley, C.S.
,
Kemp, Stephen J.
,
Teale, A.J.
,
[Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines]
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Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines
High-through put technologies inevitably produce vast quantities of data. This presents challenges in terms of developing effective analysis methods, particularly where the analysis involves combining data derived from different experimental technologies. In this investigation, a systematic appro...
Rennie, C.
,
Hulme, H.
,
Fisher, P.
,
Halp, L.
,
Agaba, Morris
,
Noyes, H.A.
,
Kemp, Stephen J.
,
Brass, A.
,
[A systematic, data-driven approach to the combined analysis of microarray and QTL data]
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A systematic, data-driven approach to the combined analysis of microarray and QTL data
To examine differences in cytokine profiles that may confer tolerance/susceptibility to bovine African trypanosomiasis, N'Dama (trypanotolerant, n = 8) and Boran (trypanosusceptible, n = 8) cattle were experimentally challenged with Trypanosoma congolense. Blood samples were collected over a 34-d...
O'Gorman, G.M.
,
Park, S.D.E.
,
Hill, E.W.
,
Meade, K.G.
,
Mitchell, L.C.
,
Agaba, Morris
,
Gibson, John P.
,
Hanotte, Olivier H.
,
Naessens, Jan
,
Kemp, Stephen J.
,
MacHugh, D.E.
,
[Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense]
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Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense
Trypanosoma congolense is a protozoan parasite that causes severe diseases in livestock. Three major quantative trait loci (QTL), Tir1, Tir2, and Tir3, control the survival time of mice after infection with T. congolense. Congenic mice carrying the C57BL/6 resistance alleles on the A/J background...
Rathkolb, B.
,
Noyes, H.A.
,
Brass, A.
,
Dark, P.
,
Fuchs, H.
,
Gailus-Durner, V.
,
Gibson, John P.
,
Angelis, M.H. de
,
Ogugo, M.
,
Iraqi, F.A.
,
Kemp, Stephen J.
,
Naessens, Jan
,
Pope, M.E.
,
Wolf, E.
,
Agaba, Morris
,
[Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection]
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Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection
Trypanosoma congolense are extracellular protozoan parasites of the blood stream of artiodactyls and are one of the main constraints on cattle production in Africa. In cattle, anaemia is the key feature of disease and persists after parasitaemia has declined to low or undetectable levels, but tre...
Noyes, H.A.
,
Alimohammadian, M.H.
,
Agaba, Morris
,
Brass, A.
,
Fuchs, H.
,
Gailus-Durner, V.
,
Hulme, H.
,
Iraqi, F.A.
,
Kemp, Stephen J.
,
Rathkolb, B.
,
Wolf, E.
,
Angelis, M.H. de
,
Roshandel, D.
,
Naessens, Jan
,
[Mechanisms controlling anaemia in Trypanosoma congolense infected mice]
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Mechanisms controlling anaemia in Trypanosoma congolense infected mice
Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the the severe anaemia and production ...