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This study aimed to provide the foundation for an integrative approach to the identification of the mechanisms underlying the response to infection with Trypanosoma congolense, and to identify pathways that have previously been overlooked. We undertook a large-scale gene expression analysis study...


Kierstein, S.Noyes, H.Naessens, JanNakamura, Y.Pritchard, J.Gibson, John P.Kemp, Stephen J.Brass, A.[Gene expression profiling in a mouse model for African trypanosomiasis]Gene expression profiling in a mouse model for African trypanosomiasis

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...


Kemp, Stephen J.Iraqi, F.A.Darvasi, A.Soller, M.Teale, A.J.[Localization of genes controlling resistance to trypanosomiasis in mice]Localization of genes controlling resistance to trypanosomiasis in mice

African trypanosomes are protozoan parasites that cause “sleeping sickness” in humans and a similar disease in livestock. Trypanosomes also infect laboratory mice and three major quantitative trait loci (QTL) that regulate survival time after infection with T. congolense have been identified in t...


Goodhead, I.Archibald, A.L.Amwayi, P.Brass, A.Gibson, John P.Hall, N.Hughes, Monica A.Limo, M.K.H.Iraqi, F.A.Kemp, Stephen J.Noyes, H.A.[A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice]A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice

Some West African Bos taurus cattle breeds such as the N'Dama and a number of West African Shorthorns are resistant to tsetse fly-transmitted trypanosomosis. The trait is termed trypanotolerance, for which changes in packed red cell volume percent (PCV) and growth rate following infection are ge...


Waaij, E.H. van derHanotte, Olivier H.Arendonk, Johan A.M. vanKemp, Stephen J.Kennedy, D.Gibson, John P.Teale, A.J.[Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle]Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle
Mingyan YuMuteti, C.Ogugo, M.Kemp, Stephen J.[African trypanosomiasis resistance in cattle by a transgenic approach]African trypanosomiasis resistance in cattle by a transgenic approach

A two species comparative genome scanning approach has been taken to mapping, and eventually identifying, genes at quantitative trait loci (QTL) influencing resistance to trypanosomosis due to infection with Trypanosoma congolense. Using two large murine F2 and two F6 advanced intercross populati...


Teale, A.J.Agaba, MorrisClapcott, S.J.Gelhaus, A.Haley, C.Psifidis, A.Horstmann, R.Iraqui, F.Kemp, Stephen J.Nilsson, P.Schwerin, M.Sekikawa, K.Soller, M.Sugimoto, Y.Womack, J.[Resistance to trypanosomosis: Of markers, genes and mechanisms]Resistance to trypanosomosis: Of markers, genes and mechanisms

It is increasingly common to combine Microarray and Quantitative Trait Loci data to aid the search for candidate genes responsible for phenotypic variation. Workflows provide a means of systematically processing these large datasets and also represent a framework for the re-use and the explicit d...


Fisher, P.Hedeler, C.Wolstencroft, K.Hulme, H.Noyes, H.Kemp, Stephen J.Stevens, R.Brass, A.[A systematic strategy for large-scale analysis of genotype-phenotype correlations: identification of candidate genes involved in African trypanosomiasis]A systematic strategy for large-scale analysis of genotype-phenotype correlations: identification of candidate genes involved in African trypanosomiasis
Hanotte, Olivier H.Korol, A.Agaba, MorrisNilsson, P.Gelhaus, P.Horstmann, R.Sugimoto, Y.Kemp, Stephen J.Soller, J.Teale, A.J.[Mapping of QTL controlling resistance to trypanosomosis in N'Dama X Boran cattle]Mapping of QTL controlling resistance to trypanosomosis in N'Dama X Boran cattle

C57BL/6J mice are relatively resistant to trypanosomosis compared to BALB/c or A/J mice. Bloodstream trypanosomes are partly dependent on the host for lipid supply and the plasma lipid levels differ between resistant and susceptible mice. Furthermore, genes controlling plasma lipid levels are dif...


Hassan, M.Agaba, MorrisBulimo, WallaceNoyes, H.Brass, A.Hinsley, T.Iraqi, F.A.Kemp, Stephen J.[Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis]Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis
Ng'ang'a, J.Gibson, John P.Imbuga, J.Kemp, Stephen J.Iraqi, F.A.[Towards fine mapping trypanosomiasis resistance QTL Tir 2 and 3 using F12 Tir1 depleted advanced intercross line population. Abstract]Towards fine mapping trypanosomiasis resistance QTL Tir 2 and 3 using F12 Tir1 depleted advanced intercross line population. Abstract

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