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Kemp, Stephen J.Tucker, E.M.Alberti, S.MacHugh, Niall D.Toye, Philip G.[A product of a second BoLA class I locus detected by a bovine monoclonal antibody]A product of a second BoLA class I locus detected by a bovine monoclonal antibody
Teale, A.J.Kemp, Stephen J.Bensaid, A.Pereira, H.[A non-MHC polymorphic system of bovine panleucocyte antigens characterized by monoclonal antibodies]A non-MHC polymorphic system of bovine panleucocyte antigens characterized by monoclonal antibodies

Microarrays are an important and widely used tool. Applications include capturing genomic DNA for high-throughput sequencing in addition to the traditional monitoring of gene expression and identifying DNA copy number variations. Sequence mismatches between probe and target strands are known to a...


Rennie, C.Noyes, H.A.Kemp, Stephen J.Hulme, H.Brass, A.Hoyle, D.C.[Strong position-dependent effects of sequence mismatches on signal ratios measured using long oligonucleotide microarrays]Strong position-dependent effects of sequence mismatches on signal ratios measured using long oligonucleotide microarrays

Inbred strains of laboratory mice exhibit marked differences in survival time following infection with Trypanosoma congolense, the principal cause of trypanosomiasis in African livestock.The difference in survival time between the relatively resistant C57BL/6 J and more susceptible BALB/c inbred ...


Clapcott, S.J.Teale, A.J.Kemp, Stephen J.[Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice]Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice

We have previously reported the results of genome-wide searches in two murine F2 populations for QTLs that influence survival following Trypanosoma congolense infection. Three loci, Tir1, Tir2, and Tir3, were identified and mapped to mouse Chromosomes (Chrs) 17, 5, and 1 respectively, with confid...


Iraqi, F.A.Clapcott, S.J.Kumari, P.Haley, C.S.Kemp, Stephen J.Teale, A.J.[Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines]Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines

High-through put technologies inevitably produce vast quantities of data. This presents challenges in terms of developing effective analysis methods, particularly where the analysis involves combining data derived from different experimental technologies. In this investigation, a systematic appro...


Rennie, C.Hulme, H.Fisher, P.Halp, L.Agaba, MorrisNoyes, H.A.Kemp, Stephen J.Brass, A.[A systematic, data-driven approach to the combined analysis of microarray and QTL data]A systematic, data-driven approach to the combined analysis of microarray and QTL data

Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and...


Hanotte, Olivier H.Ronin, Y.Agaba, MorrisNilsson, P.Gelhaus, A.Horstmann, R.Sugimoto, Y.Kemp, Stephen J.Gibson, John P.Korol, A.Soller, M.Teale, A.J.[Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle]Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle

To examine differences in cytokine profiles that may confer tolerance/susceptibility to bovine African trypanosomiasis, N'Dama (trypanotolerant, n = 8) and Boran (trypanosusceptible, n = 8) cattle were experimentally challenged with Trypanosoma congolense. Blood samples were collected over a 34-d...


O'Gorman, G.M.Park, S.D.E.Hill, E.W.Meade, K.G.Mitchell, L.C.Agaba, MorrisGibson, John P.Hanotte, Olivier H.Naessens, JanKemp, Stephen J.MacHugh, D.E.[Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense]Cytokine mRNA profiling of peripheral blood mononuclear cells from trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense

To assess the level and spatial pattern of genetic diversity of the common dormouse, Muscardinus avellanarius, we developed polymorphic microsatellite loci from partial genomic libraries enriched for microsatellite motifs. Ten dinucleotide polymorphic microsatellites were isolated and levels of g...


Naim, D.M.D.Kemp, Stephen J.Telfer, S.Watts, P.C.[Isolation and characterization of 10 microsatellite loci in the common dormouse Muscardinus avellanarius]Isolation and characterization of 10 microsatellite loci in the common dormouse Muscardinus avellanarius

Trypanosoma congolense is a protozoan parasite that causes severe diseases in livestock. Three major quantative trait loci (QTL), Tir1, Tir2, and Tir3, control the survival time of mice after infection with T. congolense. Congenic mice carrying the C57BL/6 resistance alleles on the A/J background...


Rathkolb, B.Noyes, H.A.Brass, A.Dark, P.Fuchs, H.Gailus-Durner, V.Gibson, John P.Angelis, M.H. deOgugo, M.Iraqi, F.A.Kemp, Stephen J.Naessens, JanPope, M.E.Wolf, E.Agaba, Morris[Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection]Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection

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