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Kemp, Stephen J.Spooner, R.L.Teale, A.J.[A comparative study of major histocompatibility complex antigens in East African and European cattle breeds]A comparative study of major histocompatibility complex antigens in East African and European cattle breeds

A panel of 81 new polymorphic bovine microsatellite markers is described, together with further information on a previously reported group of 16 markers. The mean polymorphism information content of the 97 markers determined in 20 cattle was 0.66. Seventy-three of these markers have been assigned...


Kemp, Stephen J.Hishida, OWambugu, J.Rink, A.Longeri, M.L.Ma, R.Z.Da, Y.Lewin, H.A.Barendse, W.Teale, A.J.[A panel of polymorphic bovine, ovine and caprine microsatellite markers]A panel of polymorphic bovine, ovine and caprine microsatellite markers

A small number of west African Bos taurus cattle breeds, including the N'Dama, constitute a valuable genetic resource by virtue of their ability to remain productive under trypanosomiasis challenge. However, introgression of Bos indicus genes into the trypanotolerant breeds, particularly by intro...


Teale, A.J.Wambugu, J.Gwakisa, P.S.Stranzinger, G.Bradley, D.Kemp, Stephen J.[A polymorphism in randomly amplified DNA which differentiates the Y chromosomes of Bos indicus and Bos taurus]A polymorphism in randomly amplified DNA which differentiates the Y chromosomes of Bos indicus and Bos taurus
Iraqi, F.A.Kemp, Stephen J.Teale, A.J.[Fine mapping of trypanosomiasis resistance QTLs in mice using advanced intercross lines]Fine mapping of trypanosomiasis resistance QTLs in mice using advanced intercross lines

Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the severe anaemia and production loss...


Kemp, Stephen J.Teale, A.J.[The genetic basis of trypanotolerance in mice and cattle]The genetic basis of trypanotolerance in mice and cattle

We describe 10 polymorphic tetranucleotide microsatellite loci from the eastern Canary Island lacertid lizard, Gallotia atlantica. Loci were isolated from a partial genomic library that had been enriched for AAAG repeat sequence. All loci were highly polymorphic (eight alleles or more) with obser...


Bloor, P.Laguna, I.H.B.Kemp, Stephen J.[Highly polymorphic tetranucleotide microsatellite loci for the eastern Canary Island lizard, Gallotia atlantica]Highly polymorphic tetranucleotide microsatellite loci for the eastern Canary Island lizard, Gallotia atlantica

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...


Kemp, Stephen J.Iraqi, F.A.Darvasi, A.Soller, M.Teale, A.J.[Localisation of genes controlling resistance to trypanosomiasis in mice]Localisation of genes controlling resistance to trypanosomiasis in mice

Differences in gene expression may be caused by nearby DNA polymorphisms (cis regulation) or by interactions of gene control regions with polymorphic transcription factors (trans regulation). Trans acting loci are much harder to detect than cis acting loci and their effects are much more sensitiv...


Noyes, H.A.Agaba, MorrisAnderson, S.Archibald, A.L.Brass, A.Gibson, John P.Hall, L.Hulme, H.Oh, S.J.Kemp, Stephen J.[Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background]Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background

An international multidisciplinary consortium is conducting a programme of research on the host response to trypanosome infection. This builds upon quantitative trait loci (QTL) mapping which identified genome regions influencing susceptibility to pathology following T. congolense infection in bo...


Kemp, Stephen J.Hanotte, Olivier H.Agaba, MorrisNoyes, H.A.Gibson, John P.Archibald, A.L.Rennie, C.Hulme, H.Brass, A.[Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons]Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons

This study aimed to provide the foundation for an integrative approach to the identification of the mechanisms underlying the response to infection with Trypanosoma congolense, and to identify pathways that have previously been overlooked. We undertook a large-scale gene expression analysis study...


Kierstein, S.Noyes, H.Naessens, JanNakamura, Y.Pritchard, J.Gibson, John P.Kemp, Stephen J.Brass, A.[Gene expression profiling in a mouse model for African trypanosomiasis]Gene expression profiling in a mouse model for African trypanosomiasis

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