African animal trypanosomiasis (AAT) caused by tsetse fly-transmitted protozoa of the genus Trypanosoma is a major constraint on livestock and agricultural production in Africa and is among the top ten global cattle diseases impacting on the poor. Here we show that a functional genomics approach ...
O'Gorman, G.M.
,
Park, S. de
,
Hill, E.W.
,
Meade, K.G.
,
Coussens, P.M.
,
Agaba, Morris
,
Naessens, Jan
,
Kemp, Stephen J.
,
MacHugh, D.E.
,
[Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility]
,
Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility
A preliminary search for QTLs in a cattle F2 resource populations segregating for trypanotolerance has revealed three large candidate chromosomal regions (Bta02, Bta05, Bta07). In order to narrow down the position of the trypanotolerant QTLs, we are building comparative chromosomal maps between c...
Nilsson, P.H.
,
Kang'a, S.
,
Rottengatter, K.
,
Suedbeck, U.
,
Iraqui, F.
,
Mwakaya, J.
,
Mwangi, D.
,
Womack, J.E.
,
Goldammer, T.
,
Schwerin, M.
,
Bradley, D.
,
Agaba, Morris
,
Sugimoto, K.
,
Gelhaus, A.
,
Horstmann, R.
,
Teale, A.J.
,
Kemp, Stephen J.
,
Hanotte, Olivier H.
,
[Radiation hybrid maps of candidate trypanotolerance regions in cattle]
,
Radiation hybrid maps of candidate trypanotolerance regions in cattle
We have sought to test the possibility of detecting regions of the genome under selection through effects on variation at linked neutral genetic markers. Particularly, we investigated three genomic regions identified by mapping in a cross-bred pedigree as harbouring QTL for trypanosomiasis tolera...
Park, S.D.E.
,
Adomefa, K.
,
Dao, B.
,
Hanotte, Olivier H.
,
Kemp, Stephen J.
,
Sow, R.S.
,
Teale, A.J.
,
Bradley, D.G.
,
[Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance]
,
Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance
West African N'Dama cattle have developed a genetic capacity to survive, reproduce and remain productive under trypanosomosis risk. The cellular and molecular bases of this so-called trypanotolerance are not known, but the trait is manifested by the N'Dama's greater capacity to control parasitae...
Naessens, Jan
,
Leak, S.G.A.
,
Kennedy, D.J.
,
Kemp, Stephen J.
,
Teale, A.J.
,
[Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense]
,
Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense
To map the genetic sources of trypanotolerance in mice, a linkage analysis of survival following trypanosome challenge was performed by selective genotyping in a large F2 population produced by crossing the resistant C57BL/6 and susceptible BALB/c inbred mouse lines. We report evidence of a chrom...
Kemp, Stephen J.
,
Darvasi, A.
,
Soller, M.
,
Teale, A.J.
,
[Genetic control of resistance to trypanosomiasis]
,
Genetic control of resistance to trypanosomiasis
Inbred strains of laboratory mice exhibit marked differences in survival time following infection with Trypanosoma congolense, the principal cause of trypanosomiasis in African livestock.The difference in survival time between the relatively resistant C57BL/6 J and more susceptible BALB/c inbred ...
Clapcott, S.J.
,
Teale, A.J.
,
Kemp, Stephen J.
,
[Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice]
,
Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice
Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the severe anaemia and production loss...
Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...
Kemp, Stephen J.
,
Iraqi, F.A.
,
Darvasi, A.
,
Soller, M.
,
Teale, A.J.
,
[Localisation of genes controlling resistance to trypanosomiasis in mice]
,
Localisation of genes controlling resistance to trypanosomiasis in mice
This study aimed to provide the foundation for an integrative approach to the identification of the mechanisms underlying the response to infection with Trypanosoma congolense, and to identify pathways that have previously been overlooked. We undertook a large-scale gene expression analysis study...
Kierstein, S.
,
Noyes, H.
,
Naessens, Jan
,
Nakamura, Y.
,
Pritchard, J.
,
Gibson, John P.
,
Kemp, Stephen J.
,
Brass, A.
,
[Gene expression profiling in a mouse model for African trypanosomiasis]
,
Gene expression profiling in a mouse model for African trypanosomiasis
Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...
Kemp, Stephen J.
,
Iraqi, F.A.
,
Darvasi, A.
,
Soller, M.
,
Teale, A.J.
,
[Localization of genes controlling resistance to trypanosomiasis in mice]
,
Localization of genes controlling resistance to trypanosomiasis in mice