Conditions were established to obtain depletion of T lymphocyte subsets in lymphoid tissues of calves by injection of mouse monoclonal antibodies to T cell antigens. Adverse reactions were avoided by injecting small quantities of antibody until target cells had disappeared from blood. Two differe...
Naessens, Jan
,
Scheerlinck, J.P.
,
Buysscher, E.V. de
,
Kennedy, D.
,
Sileghem, M.R.
,
[Effective in vivo depletion of T cell subpopulations and loss of memory cells in cattle using mouse monoclonal antibodies]
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Effective in vivo depletion of T cell subpopulations and loss of memory cells in cattle using mouse monoclonal antibodies
Some West African Bos taurus cattle breeds such as the N'Dama and a number of West African Shorthorns are resistant to tsetse fly-transmitted trypanosomosis. The trait is termed trypanotolerance, for which changes in packed red cell volume percent (PCV) and growth rate following infection are ge...
Waaij, E.H. van der
,
Hanotte, Olivier H.
,
Arendonk, Johan A.M. van
,
Kemp, Stephen J.
,
Kennedy, D.
,
Gibson, John P.
,
Teale, A.J.
,
[Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle]
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Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle
Trypanosomiasis is a serious constraint to livestock production in sub-Saharan Africa. Some breeds of cattle are genetically more resistant to the pathogenic effects of trypanosome infection. We measured B-cell activation and the quantity and isotype of antibody produced at the cellular level in ...
Taylor, K.A.
,
Lutje, V.
,
Kennedy, D.
,
Authié, E.
,
Boulange, A.F.
,
Logan-Henfrey, L.L.
,
Gichuki, B.
,
Gettinby, G.
,
[Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle]
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Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle
A comparison of T-cell-mediated immune responses in trypanotolerant N'Dama and susceptible Boran cattle during primary infection with tsetse-transmitted Trypanosoma congolense was conducted to assess whether different patterns of T-cell activation occurred during trypanosome infection. Proliferat...
Lutje, V.
,
Taylor, K.A.
,
Kennedy, D.
,
Authié, E.
,
Boulange, A.F.
,
Gettinby, G.
,
[Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection]
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Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection
The first part of the paper describes embryo transfer in detail. The ILRAD herd of N'Damas has been increased using embryo transfer. The ILRAD experiment requiring the majority of the embryo transfer work is a project to locate the genes responsible for trypanotolerance in the N'Dama. Two generat...