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Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-α (TNF-α), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia develop...


Naessens, JanKitani, H.Nakamura, Y.Yagi, Y.Sekikawa, K.Iraqi, F.A.[TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection]TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection

C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-α) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-α genes was correlated with the capacity to control parasitaemia and with survi...


Naessens, JanKitani, H.Momotani, E.Sekikawa, K.Nthale, J.M.Iraqi, F.A.[Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response]Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response

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