Salp15, a 15-kDa tick salivary gland protein, has several suppressive modes of activity against host immunity and plays a critical role in the transmission of Lyme disease spirochetes in Ixodes scapularis and Ixodes ricinus, major vectors of Lyme disease in North America and Western Europe. Salp1...
Murase, Y.
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Konnai, S.
,
Yamada, S.
,
Githaka, Naftaly W.
,
Isezaki, M.
,
Ito, T.
,
Takano, A.
,
Ando, S.
,
Kawabata, H.
,
Murata, S.
,
Ohashi, K.
,
[An investigation of binding ability of Ixodes persulcatus Schulze Salp15 with Lyme disease spirochetes]
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An investigation of binding ability of Ixodes persulcatus Schulze Salp15 with Lyme disease spirochetes
Ixodes ricinus immunosuppressor (Iris) is a tick salivary gland protein derived from I. ricinus. In this study, Iris homolog was identified in the salivary glands of Ixodes persulcatus, which is the specific vector of the Lyme disease agent in Japan. The homolog was named Ipis-1. To investigate t...
Toyomane, K.
,
Konnai, S.
,
Niwa, A.
,
Githaka, Naftaly W.
,
Isezaki, M.
,
Yamada, S.
,
Ito, T.
,
Takano, A.
,
Ando, S.
,
Kawabata, H.
,
Murata, S.
,
Ohashi, K.
,
[Identification and the preliminary in vitro characterization of IRIS homologue from salivary glands of Ixodes persulcatus Schulze]
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Identification and the preliminary in vitro characterization of IRIS homologue from salivary glands of Ixodes persulcatus Schulze
Inorganic PPases are essential metal-dependent enzymes that convert pyrophosphate into orthophosphate. This reaction is quite exergonic and provides a thermodynamic advantage for many ATP-driven biosynthetic reactions. We have previously demonstrated that cytosolic PPase from R. microplus embryos...
Costa, E.P.
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Façanha, A.R.
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Cruz, C.S.
,
Silva, J.N.
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Machado, J.A.
,
Carvalho, G.M.
,
Fernandes, M.R.
,
Martins, R.
,
Campos, E.
,
Romeiro, N.C.
,
Githaka, Naftaly W.
,
Konnai, S.
,
Ohashi, K.
,
Vaz, I.S.
,
Logullo, C.
,
[A novel mechanism of functional cooperativity regulation by thiol redox status in a dimeric inorganic pyrophosphatase]
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A novel mechanism of functional cooperativity regulation by thiol redox status in a dimeric inorganic pyrophosphatase
Among arthropods, ticks lead as vectors of animal diseases and rank second to mosquitoes in transmitting human pathogens. Cyclin-dependent kinases (CDK) participate in cell cycle control in eukaryotes. CDKs are serine/threonine protein kinases and these catalytic subunits are activated or inactiv...
Gomes, H.
,
Moraes, J.
,
Githaka, Naftaly W.
,
Martins, R.
,
Isezaki, M.
,
Silva Vaz, I. da
,
Logullo, C.
,
Konnai, S.
,
Ohashi, K.
,
[Vaccination with cyclin-dependent kinase tick antigen confers protection against Ixodes infestation]
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Vaccination with cyclin-dependent kinase tick antigen confers protection against Ixodes infestation
Githaka, Naftaly W.
,
Odongo, D.
,
Lekolool, I.
,
Konnai, S.
,
Bishop, Richard P.
,
[Novel Theileria genotypes from wildlife in a Theileria parva—Endemic area in Kenya]
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Novel Theileria genotypes from wildlife in a Theileria parva—Endemic area in Kenya
Githaka, Naftaly W.
,
Konnai, S.
,
Bishop, Richard P.
,
Odongo, D.
,
Lekolool, I.
,
Kariuki, E.
,
Gakuya, F.
,
Kamau, L.
,
Isezaki, M.
,
Murata, S.
,
Ohashi, K.
,
[Identification and sequence characterization of novel Theileria genotypes from the waterbuck (Kobus defassa) in a Theileria parva-endemic area in Kenya]
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Identification and sequence characterization of novel Theileria genotypes from the waterbuck (Kobus defassa) in a Theileria parva-endemic area in Kenya