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Abstract Background Host single-nucleotide polymorphisms (SNPs) near the interleukin 28B (IL28B) locus are associated with sustained virological response to antiviral therapy and with spontaneous Hepatitis C Virus (HCV) clearance. Prevalence of these...


Echeverría, NataliaAngulo, JennifferLópez Lastra, Marcelo AndrésChiodi, DanielaLópez, PabloSanchez Ciceron, AdrianaSilvera, PaolaCanavesi, AdrianBianchi, CarlaColistro, Valentina[IL28B gene polymorphism rs12979860, but not rs8099917, contributes to the occurrence of chronic HCV infection in Uruguayan patients]IL28B gene polymorphism rs12979860, but not rs8099917, contributes to the occurrence of chronic HCV infection in Uruguayan patients

Abstract Background Andes virus (ANDV), a rodent-borne Hantavirus, is the major etiological agent of Hantavirus cardiopulmonary syndrome (HCPS) in South America, which is mainly characterized by a vascular leakage with high rate of fatal outcomes for...


Marsac, DelphineGarcía, StephaniePino, KarlaFerrés, MarcelaLópez Lastra, Marcelo AndrésKalergis, Alexis M.Fournet, AlexandraAguirre, AdamVeas, Francisco[Infection of human monocyte-derived dendritic cells by ANDES Hantavirus enhances pro-inflammatory state, the secretion of active MMP-9 and indirectly enhances endothelial permeability]Infection of human monocyte-derived dendritic cells by ANDES Hantavirus enhances pro-inflammatory state, the secretion of active MMP-9 and indirectly enhances endothelial permeability

Abstract Background The human immunodeficiency virus type 1 (HIV-1) Tat protein is a major viral transactivator required for HIV-1 replication. In the nucleus Tat greatly stimulates the synthesis of full-length transcripts from the HIV-1 promoter by ...


Charnay, NicolasLópez Lastra, Marcelo AndrésIvanyi-Nagy, RolandSoto Rifo, RicardoOhlmann, ThéophileDarlix, Jean-Luc[Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein]Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein

Abstract Dicistronic MLV-based retroviral vectors, in which two IRESes independently initiate the translation of two proteins from a single RNA, have been shown to direct co-expression of proteins in several cell culture systems. Here we report that these dicistronic retroviral vect...


López Lastra, Marcelo AndrésDerrington, Edmund A.Darlix, Jean-Luc.[Dicistronic MLV-retroviral vectors transduce neural precursors in vivoand co-express two genes in their differentiated neuronal progeny]Dicistronic MLV-retroviral vectors transduce neural precursors in vivoand co-express two genes in their differentiated neuronal progeny
Angulo, J.Ulryck, N.Deforges, J.Chamond, N.López Lastra, Marcelo AndrésMasquida, B.Sargueil, B.[LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex]LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex
Monrroy, HugoAngulo, J.Pino, KarlaLabbé, P.López Lastra, Marcelo AndrésSoza, Alejandro[Effect of ezetimibe in HCV viral load after liver transplantation]Effect of ezetimibe in HCV viral load after liver transplantation
Cáceres, C. JoaquínAngulo, JennifferContreras, NatalyPino, KarlaVera Otarola, JorgeLópez Lastra, Marcelo Andrés[Targeting deoxyhypusine hydroxylase activity impairs cap-independent translation initiation driven by the 5'untranslated region of the HIV-1, HTLV-1, and MMTV mRNAs]Targeting deoxyhypusine hydroxylase activity impairs cap-independent translation initiation driven by the 5'untranslated region of the HIV-1, HTLV-1, and MMTV mRNAs
Morales, M.Flores, C.Pino, KarlaAngulo, J.López Lastra, Marcelo AndrésCastro Rodríguez, José A.[Urinary leukotriene and Bcl I polymorphism of glucocorticoid receptor gene in preschoolers with recurrent wheezing and high risk of asthma]Urinary leukotriene and Bcl I polymorphism of glucocorticoid receptor gene in preschoolers with recurrent wheezing and high risk of asthma
Monrroy, HugoAngulo, J.Pino, KarlaLabbé, P.Miquel Poblete, Juan FranciscoLópez Lastra, Marcelo AndrésSoza, Alejandro[Detection of high biliary and fecal viral loads in patients with chronic hepatitis C virus infection]Detection of high biliary and fecal viral loads in patients with chronic hepatitis C virus infection

Latin America is a diverse region with more than 500 million people and approximately 8 million HCV infected individuals. The recent description of genetic polymorphisms associated to the interleukin 28B gene that predicts the response to treatment in these patients has impacted the clinical algo...


Soza, AlejandroLópez Lastra, Marcelo Andrés[IL28B Polymorphisms Among Latin American HCV Patients]IL28B Polymorphisms Among Latin American HCV Patients

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