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The dual potential to promote tolerance or inflammation to self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. Previous results have shown that stimulation of dopamine receptor D5 (DRD5) in DCs potentiates their inflammatory behaviour, favouring the development of exper...


Prado, C.Gaiazzi, M.González, H.Ugalde, V.Figueroa, A.Osorio-Barrios, F.J.López, E.Lladser, A.Rasini, E.Marino, F.Zaffaroni, M.Cosentino, M.Pacheco, R.[Dopaminergic stimulation of myeloid antigen-presenting cells attenuates signal transducer and activator of transcription 3-activation favouring the development of experimental autoimmune encephalomyelitis]Dopaminergic stimulation of myeloid antigen-presenting cells attenuates signal transducer and activator of transcription 3-activation favouring the development of experimental autoimmune encephalomyelitis

Dendritic cell (DC) trafficking from peripheral tissues to lymph nodes (LNs) is a key step required to initiate T cell responses against pathogens as well as tumors. In this context, cellular membrane protrusions and the actin cytoskeleton are essential to guide DC migration towards chemotactic s...


Oyarce, C.Cruz-Gomez, S.Galvez-Cancino, F.Vargas, P.Moreau, H.D.Diaz-Valdivia, N.Diaz, J.Salazar-Onfray, F.A.Pacheco, R.Lennon-Dumenil, A.M.Quest, A.F.G.Lladser, A.[Caveolin-1 expression increases upon maturation in dendritic cells and promotes their migration to lymph nodes thereby favoring the induction of CD8+ T cell responses]Caveolin-1 expression increases upon maturation in dendritic cells and promotes their migration to lymph nodes thereby favoring the induction of CD8+ T cell responses

Memory CD8+ T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8+ T cell effector subsets to persist and become memory cells has not been fully characterized. Type...


Flores-Santibáñez, F.Cuadra, B.Fernández, D.Rosemblatt, M.V.Núñez, S.Cruz, P.Gálvez-Cancino, F.César Cárdenas, J.Lladser, A.Rosemblatt, M.Bono, M.R.Sauma, D.[In vitro-generated Tc17 cells present a memory phenotype and serve as a reservoir of Tc1 cells in vivo]In vitro-generated Tc17 cells present a memory phenotype and serve as a reservoir of Tc1 cells in vivo

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