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Poly(amidoamine) dendrimers are the most recognized class of dendrimer. Amino-terminated (PAMAM-NH2) and hydroxyl-terminated (PAMAM-OH) dendrimers of generation 4 are widely used, since they are commercially available. Both have different properties, mainly based on their different overall charge...


Márquez-Miranda, ValeriaPeñaloza, Juan PabloAraya-Durán, IngridReyes, RodrigoVidaurre, SoledadRomero, ValentinaFuentes, JuanCéric, FranciscoVelásquez, LuisGonzález-Nilo, Fernando D.Otero, Carolina[Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake]Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake

An ideal nucleic-acid transfection system should combine the physical and chemical characteristics of cationic lipids and linear polymers to decrease cytotoxicity and uptake limitations. Previous research described new types of carriers termed amphiphilic dendrimers (ADs), which are based on poly...


Márquez-Miranda, ValeriaAraya-Durán, IngridCamarada, María BelénComer, JeffreyValencia-Gallegos, Jesús A.González-Nilo, Fernando Danilo[Self-Assembly of Amphiphilic Dendrimers: The Role of Generation and Alkyl Chain Length in siRNA Interaction]Self-Assembly of Amphiphilic Dendrimers: The Role of Generation and Alkyl Chain Length in siRNA Interaction

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