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Kemp, Stephen J.Tucker, E.M.Alberti, S.MacHugh, Niall D.Toye, Philip G.[A product of a second BoLA class I locus detected by a bovine monoclonal antibody]A product of a second BoLA class I locus detected by a bovine monoclonal antibody
Morrison, W. IvanMacHugh, Niall D.Bensaid, A.M.Goddeeris, B.M.Teale, A.J.McKeever, Declan J.[A monoclonal antibody which reacts specifically with a population of bovine lymphocytes lacking B cell and T cell markers]A monoclonal antibody which reacts specifically with a population of bovine lymphocytes lacking B cell and T cell markers

Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated through the destruction of parasite infected lymphocytes by MHC class I restricted CD8+ CTL. Six parasite proteins targeted by CTL from T. parva immune cattle have been identified and raised...


Graham, S.P.Pelle, RogerVilliers, Etienne P. deYamage, M.Mwangi, D.M.Honda, Y.Ellis, S.A.MacHugh, Niall D.Morrison, W. IvanTaracha, E.L.N.[Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva]Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva

Species: RuminantsTheileria parva is an intracellular protozoal parasite which causes East Coast Fever (ECF), a major constraint to cattle production in eastern and southern Africa. Characteristics of the protective CD8+ T-cell response against T. parva suggest it is focused on a limited number o...


Connelley, T.MacHugh, Niall D.Graham, S.Taracha, E.A.Burrells, A.Ngugi, D.Morrison, W. Ivan[The bovine CD8+ T-cell response to Theileria parva displays epitope immunodominance and oligoclonality]The bovine CD8+ T-cell response to Theileria parva displays epitope immunodominance and oligoclonality

We describe a highly sensitive, non-radioactive assay for T cell activation, based on the rapid induction of class II MHC expression by constitutively negative bovine endothelial cells, when cultured in the presence of supernatants derived from activated bovine T cells. We demonstrate the effecti...


Ballingall, K.T.Mwangi, D.M.MacHugh, Niall D.Taracha, E.L.N.Totte, P.McKeever, Declan J.[A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells]A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells

African trypansosomes are tsetse-transmitted parasites of chief importance in causing disease in livestock in regions of sub-Saharan Africa. Previous studies have demonstrated that certain breeds of cattle are relatively resistant to infection with trypanosomes, and others are more susceptible. B...


Haas, K.M.Taylor, K.A.MacHugh, Niall D.Kreeger, J.M.Estes, D.M.[Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection]Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection

We describe the characterization of two subsets of bovine gamma delta T cells having distinct cell surface phenotype and tissue distribution. One population expresses the previously described 215000 MW WC1 antigen and is negative for the cell-surface differentiation antigens CD2. CD4, and CD8. Th...


MacHugh, Niall D.Mburu, J.K.Carol, M.J.Wyatt, C.R.Orden, J.A.Davis, W.C.[Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution]Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution

Theileria parva has been shown to infect and transform B cells and T cells at similar frequencies in vitro. However, the majority of parasitized cells in the tissues of infected cattle are alpha/beta T cells. The aim of this study was to determine whether the cell type infected with T. parva infl...


Morrison, W. IvanMacHugh, Niall D.Lalor, P.A.[Pathogenicity of Theileria parva is influenced by the host cell type infected by the parasite]Pathogenicity of Theileria parva is influenced by the host cell type infected by the parasite
Davis, W.C.Ellis, J.A.MacHugh, Niall D.Baldwin, C.L.[Bovine pan T-cell monoclonal antibodies reactive with a molecule similar to CD2]Bovine pan T-cell monoclonal antibodies reactive with a molecule similar to CD2

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