Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated through the destruction of parasite infected lymphocytes by MHC class I restricted CD8+ CTL. Six parasite proteins targeted by CTL from T. parva immune cattle have been identified and raised...
Graham, S.P.
,
Pelle, Roger
,
Villiers, Etienne P. de
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Yamage, M.
,
Mwangi, D.M.
,
Honda, Y.
,
Ellis, S.A.
,
MacHugh, Niall D.
,
Morrison, W. Ivan
,
Taracha, E.L.N.
,
[Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva]
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Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva
Species: RuminantsTheileria parva is an intracellular protozoal parasite which causes East Coast Fever (ECF), a major constraint to cattle production in eastern and southern Africa. Characteristics of the protective CD8+ T-cell response against T. parva suggest it is focused on a limited number o...
Connelley, T.
,
MacHugh, Niall D.
,
Graham, S.
,
Taracha, E.A.
,
Burrells, A.
,
Ngugi, D.
,
Morrison, W. Ivan
,
[The bovine CD8+ T-cell response to Theileria parva displays epitope immunodominance and oligoclonality]
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The bovine CD8+ T-cell response to Theileria parva displays epitope immunodominance and oligoclonality
We describe the characterization of two subsets of bovine gamma delta T cells having distinct cell surface phenotype and tissue distribution. One population expresses the previously described 215000 MW WC1 antigen and is negative for the cell-surface differentiation antigens CD2. CD4, and CD8. Th...
MacHugh, Niall D.
,
Mburu, J.K.
,
Carol, M.J.
,
Wyatt, C.R.
,
Orden, J.A.
,
Davis, W.C.
,
[Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution]
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Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution
Pepin, L.
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Winjgaard, P.
,
Lehrun, D.
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MacHugh, Niall D.
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Teale, A.J.
,
Maillard, J.C.
,
Clevers, H.
,
Bensaid, A.M.
,
[Description of a new bovine multigene family encoding for markers of differentiation of y/d T-cells]
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Description of a new bovine multigene family encoding for markers of differentiation of y/d T-cells
Bensaid, A.M.
,
Kaushal, D.
,
Baldwin, C.L.
,
Clevers, H.
,
Young, J.R.
,
Kemp, Stephen J.
,
MacHugh, Niall D.
,
Toye, Philip G.
,
Teale, A.J.
,
[Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage]
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Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage
The characterisation of a monoclonal antibody (mAb), designated MM1A, which reacts with an antigen molecule on the surface of bovine alfa beta and gama delta TcR+ T cells is described. The mAb immunoprecipitated a series of polypeptides of 21 kDa, 22 kDa, 36 kDa and 44 kDa which is consistent wit...
MacHugh, Niall D.
,
Mburu, J.K.
,
Hamilton, M.J.
,
Davis, W.C.
,
[Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex]
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Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex
Davis, W.C.
,
MacHugh, Niall D.
,
Park, Y.H.
,
Hamilton, M.J.
,
Wyatt, C.R.
,
[Identification of a monoclonal antibody reactive with the bovine orthologue of CD3 (BoCD3)]
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Identification of a monoclonal antibody reactive with the bovine orthologue of CD3 (BoCD3)