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Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated through the destruction of parasite infected lymphocytes by MHC class I restricted CD8+ CTL. Six parasite proteins targeted by CTL from T. parva immune cattle have been identified and raised...


Graham, S.P.Pelle, RogerVilliers, Etienne P. deYamage, M.Mwangi, D.M.Honda, Y.Ellis, S.A.MacHugh, Niall D.Morrison, W. IvanTaracha, E.L.N.[Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva]Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva

Species: RuminantsTheileria parva is an intracellular protozoal parasite which causes East Coast Fever (ECF), a major constraint to cattle production in eastern and southern Africa. Characteristics of the protective CD8+ T-cell response against T. parva suggest it is focused on a limited number o...


Connelley, T.MacHugh, Niall D.Graham, S.Taracha, E.A.Burrells, A.Ngugi, D.Morrison, W. Ivan[The bovine CD8+ T-cell response to Theileria parva displays epitope immunodominance and oligoclonality]The bovine CD8+ T-cell response to Theileria parva displays epitope immunodominance and oligoclonality

We describe the characterization of two subsets of bovine gamma delta T cells having distinct cell surface phenotype and tissue distribution. One population expresses the previously described 215000 MW WC1 antigen and is negative for the cell-surface differentiation antigens CD2. CD4, and CD8. Th...


MacHugh, Niall D.Mburu, J.K.Carol, M.J.Wyatt, C.R.Orden, J.A.Davis, W.C.[Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution]Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution
Pepin, L.Winjgaard, P.Lehrun, D.MacHugh, Niall D.Teale, A.J.Maillard, J.C.Clevers, H.Bensaid, A.M.[Description of a new bovine multigene family encoding for markers of differentiation of y/d T-cells]Description of a new bovine multigene family encoding for markers of differentiation of y/d T-cells
Ellis, J.A.Davis, W.C.MacHugh, Niall D.[Differentiation antigens on bovine mononuclear phagocytes identified by monoclonal antibodies]Differentiation antigens on bovine mononuclear phagocytes identified by monoclonal antibodies
Bensaid, A.M.Kaushal, D.Baldwin, C.L.Clevers, H.Young, J.R.Kemp, Stephen J.MacHugh, Niall D.Toye, Philip G.Teale, A.J.[Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage]Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage

The characterisation of a monoclonal antibody (mAb), designated MM1A, which reacts with an antigen molecule on the surface of bovine alfa beta and gama delta TcR+ T cells is described. The mAb immunoprecipitated a series of polypeptides of 21 kDa, 22 kDa, 36 kDa and 44 kDa which is consistent wit...


MacHugh, Niall D.Mburu, J.K.Hamilton, M.J.Davis, W.C.[Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex]Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex
Davis, W.C.MacHugh, Niall D.Park, Y.H.Hamilton, M.J.Wyatt, C.R.[Identification of a monoclonal antibody reactive with the bovine orthologue of CD3 (BoCD3)]Identification of a monoclonal antibody reactive with the bovine orthologue of CD3 (BoCD3)

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