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Naessens, JanSileghem, M.R.MacHugh, Niall D.Park, Y.H.Davis, W.C.Toye, Philip G.[Selection of BoCD25 monoclonal antibodies by screening mouse L cells transfected with the bovine p55-interleukin-2 (IL-2) receptor gene]Selection of BoCD25 monoclonal antibodies by screening mouse L cells transfected with the bovine p55-interleukin-2 (IL-2) receptor gene
Emery, D.L.MacHugh, Niall D.Morrison, W. Ivan[Theileria parva (Muguga) infects bovine T-lymphocytes in vivo and induces coexpression of BoT4 and BoT8]Theileria parva (Muguga) infects bovine T-lymphocytes in vivo and induces coexpression of BoT4 and BoT8

Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated through the destruction of parasite infected lymphocytes by MHC class I restricted CD8+ CTL. Six parasite proteins targeted by CTL from T. parva immune cattle have been identified and raised...


Graham, S.P.Pelle, RogerVilliers, Etienne P. deYamage, M.Mwangi, D.M.Honda, Y.Ellis, S.A.MacHugh, Niall D.Morrison, W. IvanTaracha, E.L.N.[Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva]Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva

Species: RuminantsTheileria parva is an intracellular protozoal parasite which causes East Coast Fever (ECF), a major constraint to cattle production in eastern and southern Africa. Characteristics of the protective CD8+ T-cell response against T. parva suggest it is focused on a limited number o...


Connelley, T.MacHugh, Niall D.Graham, S.Taracha, E.A.Burrells, A.Ngugi, D.Morrison, W. Ivan[The bovine CD8+ T-cell response to Theileria parva displays epitope immunodominance and oligoclonality]The bovine CD8+ T-cell response to Theileria parva displays epitope immunodominance and oligoclonality

We describe a highly sensitive, non-radioactive assay for T cell activation, based on the rapid induction of class II MHC expression by constitutively negative bovine endothelial cells, when cultured in the presence of supernatants derived from activated bovine T cells. We demonstrate the effecti...


Ballingall, K.T.Mwangi, D.M.MacHugh, Niall D.Taracha, E.L.N.Totte, P.McKeever, Declan J.[A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells]A highly sensitive, non-radioactive assay for T cell activation in cattle: Applications in screening for antigens recognised by CD4+ and CD8+ T cells

Theileria parva has been shown to infect and transform B cells and T cells at similar frequencies in vitro. However, the majority of parasitized cells in the tissues of infected cattle are alpha/beta T cells. The aim of this study was to determine whether the cell type infected with T. parva infl...


Morrison, W. IvanMacHugh, Niall D.Lalor, P.A.[Pathogenicity of Theileria parva is influenced by the host cell type infected by the parasite]Pathogenicity of Theileria parva is influenced by the host cell type infected by the parasite
Martini, J.C. deMacHugh, Niall D.Naessens, JanTeale, A.J.[Differential in vitro and in vivo expression of MHC class II antigens in bovine lymphocytes infected by Theileria parva]Differential in vitro and in vivo expression of MHC class II antigens in bovine lymphocytes infected by Theileria parva

Theileria parva causes an acute lympho-proliferative disease in cattle, which can result in death of susceptible animals within 2-3 weeks of infection. Analyses of the cellular response in the lymph node draining the site of infection demonstrated an early T cell response, with the appearance of ...


Houston, E.F.Taracha, E.L.N.Brackenbury, L.MacHugh, Niall D.McKeever, Declan J.Charleston, B.Morrison, W. Ivan[Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function]Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function
McKeever, Declan J.Taracha, E.L.N.Innes, E.L.MacHugh, Niall D.Awino, EliasGoddeeris, B.M.Morrison, W. Ivan[Adoptive transfer of immunity to Theileria parva in the CD8+ fraction of responding effluent lymph]Adoptive transfer of immunity to Theileria parva in the CD8+ fraction of responding effluent lymph

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